Kidizinc
Generic Name
Zinc Sulfate (equivalent to 10 mg elemental zinc per 5 ml)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| kidizinc 10 mg syrup | ৳ 35.00 | N/A |
Description
Overview of the medicine
Kidizinc-10 mg syrup is an oral preparation of zinc sulfate, providing elemental zinc. It is used to treat and prevent zinc deficiency and as an essential adjunct in the management of acute and persistent diarrhea in children.
Uses & Indications
Dosage
Adults
Not typically used for adults in this syrup strength; consult physician for appropriate dosage form and strength (usually 20-50 mg elemental zinc daily for adults).
Elderly
No specific dose adjustment for elderly, but caution with renal function is advised. Consult physician.
Renal_impairment
Use with caution. Dosage adjustment may be required in severe cases. Consult physician.
How to Take
Kidizinc-10 mg syrup should be taken orally. It can be taken with or after food to minimize gastric upset. Shake the bottle well before use. Use the provided measuring spoon/cup for accurate dosing.
Mechanism of Action
Zinc is an essential trace element and a cofactor for over 300 enzymes involved in metabolic processes, immune function, protein synthesis, cell division, and DNA synthesis. It also plays a crucial role in maintaining structural integrity of proteins and cell membranes. In diarrhea, zinc supplementation helps to reduce stool volume, duration, and severity by improving water and electrolyte absorption, promoting regeneration of intestinal mucosa, and enhancing immune response.
Pharmacokinetics
Onset
Clinical improvement for acute conditions like diarrhea can be observed within days. For chronic deficiency, therapeutic effects may take weeks.
Excretion
Primarily excreted via feces (approximately 90%). Smaller amounts are excreted in urine and sweat.
Half life
The plasma half-life of zinc is approximately 2-3 hours, but tissue retention is much longer.
Absorption
Approximately 20-40% of orally administered zinc is absorbed, primarily from the small intestine. Absorption is influenced by dietary factors (e.g., phytates, fiber, calcium, iron) and the body's zinc status.
Metabolism
Zinc is not metabolized in the classical sense. It is incorporated into various proteins and enzymes throughout the body.
Side Effects
Contraindications
- Hypersensitivity to zinc sulfate or any component of the formulation.
Drug Interactions
Penicillamine
Zinc may reduce the absorption of penicillamine, an agent used for heavy metal poisoning. Separate dosing by several hours.
Iron supplements
High doses of iron can interfere with zinc absorption. Administer with a few hours interval.
Calcium supplements
Large amounts of calcium may reduce zinc absorption.
Tetracycline and Quinolone antibiotics
Zinc can chelate with these antibiotics, reducing their absorption and efficacy. Separate administration by at least 2-4 hours.
Storage
Store below 30°C in a cool, dry place, away from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of acute zinc overdose may include nausea, severe vomiting, diarrhea, abdominal pain, lethargy, and dizziness. Chronic high-dose zinc intake can lead to copper deficiency, with symptoms like anemia and neurological problems. Management is symptomatic and supportive, including gastric lavage or emetics if ingestion is recent.
Pregnancy & Lactation
Zinc is an essential mineral during pregnancy and lactation. Kidizinc-10 mg syrup is generally considered safe when taken at recommended doses to meet dietary needs. However, high doses should be avoided, and use should be under medical supervision.
Side Effects
Contraindications
- Hypersensitivity to zinc sulfate or any component of the formulation.
Drug Interactions
Penicillamine
Zinc may reduce the absorption of penicillamine, an agent used for heavy metal poisoning. Separate dosing by several hours.
Iron supplements
High doses of iron can interfere with zinc absorption. Administer with a few hours interval.
Calcium supplements
Large amounts of calcium may reduce zinc absorption.
Tetracycline and Quinolone antibiotics
Zinc can chelate with these antibiotics, reducing their absorption and efficacy. Separate administration by at least 2-4 hours.
Storage
Store below 30°C in a cool, dry place, away from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of acute zinc overdose may include nausea, severe vomiting, diarrhea, abdominal pain, lethargy, and dizziness. Chronic high-dose zinc intake can lead to copper deficiency, with symptoms like anemia and neurological problems. Management is symptomatic and supportive, including gastric lavage or emetics if ingestion is recent.
Pregnancy & Lactation
Zinc is an essential mineral during pregnancy and lactation. Kidizinc-10 mg syrup is generally considered safe when taken at recommended doses to meet dietary needs. However, high doses should be avoided, and use should be under medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
While specific clinical trials for 'Kidizinc-10 mg syrup' formulation may exist for bioavailability, the efficacy and safety of zinc supplementation for deficiency and diarrhea are well-established through numerous international clinical trials and meta-analyses.
Lab Monitoring
- Serum zinc levels (if monitoring deficiency or toxicity is needed).
- Serum copper levels (with prolonged high-dose zinc therapy to monitor for copper deficiency).
Doctor Notes
- Emphasize the importance of continuing zinc therapy for 10-14 days in diarrheal management, regardless of early symptom resolution.
- Advise parents/caregivers on proper measuring techniques for syrup administration in children.
- Counsel on potential drug-drug and drug-food interactions, especially with antibiotics and iron.
Patient Guidelines
- Take exactly as prescribed or directed on the package.
- Do not exceed the recommended daily dose.
- Inform your doctor or pharmacist about all other medications, vitamins, or supplements you are taking.
- For diarrhea, continue zinc supplementation for 10-14 days even if symptoms improve.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Kidizinc-10 mg syrup is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in zinc (e.g., meat, fish, nuts, whole grains).
- Ensure adequate hydration, especially during episodes of diarrhea.
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