Klokap
Generic Name
Cloxacillin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| klokap 500 mg capsule | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Cloxacillin is a penicillin antibiotic used to treat bacterial infections. It is effective against penicillinase-producing staphylococci.
Uses & Indications
Dosage
Adults
500 mg every 6 hours, usually for 7-14 days depending on infection severity. To be taken on an empty stomach.
Elderly
Same as adults, but dose adjustment may be needed in severe renal impairment.
Renal_impairment
Dose reduction may be necessary for severe renal dysfunction (e.g., CrCl <10 mL/min).
How to Take
Take on an empty stomach (at least 30 minutes before food or 2 hours after food) with a glass of water to ensure maximal absorption.
Mechanism of Action
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death.
Pharmacokinetics
Onset
Rapid, typically within 30-60 minutes for antimicrobial effect.
Excretion
Primarily excreted unchanged in the urine, with some biliary excretion.
Half life
Approximately 0.5-1 hour.
Absorption
Rapidly absorbed after oral administration, peak plasma levels reached within 1-2 hours. Food may decrease absorption.
Metabolism
Partially metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to penicillin or other beta-lactam antibiotics
- •History of cloxacillin-associated jaundice/hepatic dysfunction
Drug Interactions
Warfarin
May increase anticoagulant effect; monitor INR.
Methotrexate
May increase methotrexate levels, enhancing toxicity.
Oral Contraceptives
May reduce effectiveness of oral contraceptives.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, diarrhea, and rarely, convulsions. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Generally considered safe (Category B) during pregnancy, but use with caution. Excreted in breast milk, monitor infant for adverse effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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