ImmunoModulin
Generic Name
Kolosal
Manufacturer
Global Pharma Inc.
Country
USA
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Description
Overview of the medicine
Kolosal is a novel immunomodulator indicated for the treatment of chronic inflammatory and autoimmune diseases.
Uses & Indications
Dosage
Adults
300 mg once daily, with or without food.
Elderly
No specific dose adjustment required, but monitor for adverse effects.
Renal_impairment
Mild to moderate impairment: No adjustment. Severe impairment: Use with caution, consider dose reduction.
How to Take
Take the tablet whole with a glass of water. Do not crush, chew, or divide.
Mechanism of Action
Kolosal selectively targets specific pathways involved in chronic inflammation and immune dysregulation, thereby modulating the immune response and reducing inflammatory markers.
Pharmacokinetics
Onset
Therapeutic effects usually observed within 2-4 weeks of continuous treatment.
Excretion
Mainly excreted in urine (60%) and feces (40%).
Half life
Approximately 18-24 hours.
Absorption
Well absorbed orally; peak plasma concentration reached within 2-4 hours.
Metabolism
Primarily metabolized in the liver via CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to Kolosal or any excipients.
- Active severe infections (e.g., tuberculosis, sepsis).
- Severe hepatic impairment.
Drug Interactions
Live Vaccines
Avoid concomitant use due to increased risk of infection from live vaccines.
Other Immunosuppressants
Increased risk of infections and other adverse effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Management is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. It is unknown whether Kolosal is excreted in human milk; caution is advised during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Kolosal or any excipients.
- Active severe infections (e.g., tuberculosis, sepsis).
- Severe hepatic impairment.
Drug Interactions
Live Vaccines
Avoid concomitant use due to increased risk of infection from live vaccines.
Other Immunosuppressants
Increased risk of infections and other adverse effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Management is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. It is unknown whether Kolosal is excreted in human milk; caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Available in major pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
On-patent
Clinical Trials
Phase III clinical trials demonstrated significant efficacy and an acceptable safety profile in patients with rheumatoid arthritis.
Lab Monitoring
- Complete Blood Count (CBC) before and periodically during treatment.
- Liver Function Tests (LFTs) periodically.
- Screening for tuberculosis and viral hepatitis.
Doctor Notes
- Regular patient monitoring for infections and adverse effects is crucial.
- Educate patients on symptoms of infection and the importance of adherence.
Patient Guidelines
- Take Kolosal exactly as prescribed by your doctor.
- Report any signs of infection (fever, chills, persistent cough) immediately.
- Do not receive live vaccines while on Kolosal.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Kolosal is not known to impair the ability to drive or operate machinery. However, if you experience dizziness or other side effects that affect your concentration, avoid these activities.
Lifestyle Advice
- Maintain good hygiene to reduce infection risk.
- Avoid close contact with people who are sick.
- Follow a balanced diet and regular exercise as advised by your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.