KPR
Generic Name
Kiprozine Hydrochloride
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| kpr 10 mg tablet | ৳ 10.00 | N/A |
Description
Overview of the medicine
KPR 10 mg Tablet is an antihistamine primarily used to relieve symptoms of seasonal allergies, such as sneezing, runny nose, itchy or watery eyes, and itching of the nose or throat. It can also be used for chronic urticaria (hives) to reduce itching and rash.
Uses & Indications
Dosage
Adults
One 10 mg tablet once daily.
Elderly
No dosage adjustment is generally required unless there is significant renal impairment. Use with caution.
Renal_impairment
For patients with moderate to severe renal impairment (CrCl < 50 mL/min), a reduced dose of 5 mg every other day may be considered.
How to Take
Take KPR 10 mg Tablet orally with or without food. Swallow the tablet whole with a glass of water.
Mechanism of Action
Kiprozine Hydrochloride, the active ingredient in KPR, selectively binds to and blocks peripheral H1 histamine receptors. This prevents histamine, a natural substance produced by the body, from acting on these receptors, thereby reducing allergic symptoms.
Pharmacokinetics
Onset
1 to 2 hours
Excretion
Primarily excreted in urine and feces, predominantly as unchanged drug.
Half life
Approximately 8-12 hours
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations achieved within 1-2 hours.
Metabolism
Minimally metabolized in the liver (primarily via CYP3A4); mainly excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to Kiprozine Hydrochloride or any component of the formulation.
- Severe hepatic impairment.
Drug Interactions
Alcohol and CNS Depressants
Concomitant use may increase the risk of CNS depression and impair alertness.
Ketoconazole, Erythromycin, Cimetidine
These drugs may increase plasma concentrations of Kiprozine, though generally without significant clinical effect due to its high therapeutic index.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, and headache. In case of overdose, symptomatic and supportive measures should be initiated. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. It is not known whether Kiprozine is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Pending
Clinical Trials
Phase III clinical trials demonstrated efficacy and safety in treating seasonal allergic rhinitis and chronic idiopathic urticaria. Post-marketing surveillance is ongoing.
Lab Monitoring
- Routine lab monitoring is not typically required for healthy individuals. In patients with pre-existing hepatic or renal impairment, periodic monitoring of liver or kidney function may be advisable.
Doctor Notes
- Advise patients about potential drowsiness, especially when initiating treatment.
- Consider renal function in elderly patients or those with kidney impairment before prescribing.
- Emphasize avoiding self-medication for chronic conditions.
Patient Guidelines
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Avoid alcohol while taking this medicine as it may increase drowsiness.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
KPR may cause drowsiness in some individuals. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Identify and avoid known allergens that trigger your symptoms.
- Maintain good hygiene to reduce exposure to allergens.
- Stay hydrated by drinking plenty of fluids.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.