KTM
Generic Name
Cetirizine Hydrochloride
Manufacturer
A hypothetical Pharmaceutical Company Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ktm 10 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
KTM 10 mg Tablet contains Cetirizine Hydrochloride, a potent second-generation antihistamine. It is primarily used to relieve symptoms of seasonal and perennial allergic rhinitis, chronic idiopathic urticaria, and other allergic conditions.
Uses & Indications
Dosage
Adults
10 mg once daily, preferably in the evening.
Elderly
Initial dose 5 mg once daily, adjusted based on renal function.
Renal_impairment
Creatinine clearance 31-60 mL/min: 5 mg once daily. Creatinine clearance <31 mL/min: 5 mg every other day. Hemodialysis patients: Not recommended.
How to Take
Should be taken orally with or without food. Can be taken as a single dose in the evening.
Mechanism of Action
Cetirizine selectively antagonizes peripheral H1-receptors, thereby inhibiting the effects of histamine which include vasodilation, increased vascular permeability, and itching.
Pharmacokinetics
Onset
Within 20-60 minutes
Excretion
Mainly via urine (about 70% as unchanged drug) and to a lesser extent via feces.
Half life
Approximately 8-10 hours in adults
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached within 1 hour.
Metabolism
Minimal hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivatives.
- Severe renal impairment (creatinine clearance <10 mL/min).
Drug Interactions
Theophylline
A small decrease in cetirizine clearance has been observed, though unlikely to be clinically significant.
CNS Depressants (e.g., alcohol, sedatives)
Increased risk of drowsiness and CNS depression.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, somnolence, agitation, and restlessness. Management involves symptomatic and supportive care, gastric lavage if recent ingestion.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, so use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivatives.
- Severe renal impairment (creatinine clearance <10 mL/min).
Drug Interactions
Theophylline
A small decrease in cetirizine clearance has been observed, though unlikely to be clinically significant.
CNS Depressants (e.g., alcohol, sedatives)
Increased risk of drowsiness and CNS depression.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, somnolence, agitation, and restlessness. Management involves symptomatic and supportive care, gastric lavage if recent ingestion.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, so use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established cetirizine's efficacy and safety for allergic conditions, demonstrating significant symptom reduction compared to placebo.
Lab Monitoring
- No specific routine lab monitoring is required for healthy individuals.
- Liver and kidney function tests may be considered in patients with pre-existing impairment.
Doctor Notes
- Advise patients about potential for drowsiness, especially with initial doses or concomitant alcohol use.
- Consider dose adjustment in elderly patients and those with renal impairment.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid consuming alcohol while taking this medicine, as it may increase drowsiness.
- Inform your doctor if symptoms do not improve or worsen.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause drowsiness or dizziness. Avoid driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Identify and avoid known allergens.
- Maintain good indoor air quality.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.