KX-100
Generic Name
Hypothetical Active Ingredient 100 mg Tablet
Manufacturer
Apex Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| kx 100 100 mg tablet | ৳ 50.14 | N/A |
Description
Overview of the medicine
KX-100 100 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used for pain relief and reducing inflammation. It helps in managing various painful conditions such as osteoarthritis, rheumatoid arthritis, and dysmenorrhea.
Uses & Indications
Dosage
Adults
100 mg once or twice daily, or as directed by physician. Max 200 mg/day.
Elderly
Lower initial doses may be required, careful monitoring for adverse effects is advised. Consult physician.
Renal_impairment
Use with caution in mild to moderate impairment. Not recommended in severe renal impairment.
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole; do not crush, chew, or break it.
Mechanism of Action
It works by inhibiting cyclooxygenase (COX) enzymes, primarily COX-2, which are responsible for the synthesis of prostaglandins, mediators of inflammation, pain, and fever.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Primarily excreted in urine as metabolites, a small amount in feces.
Half life
Approximately 2-4 hours.
Absorption
Well absorbed orally, peak plasma levels reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes.
Side Effects
Contraindications
- Known hypersensitivity to NSAIDs or any component of KX-100
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Severe uncontrolled heart failure
- Coronary Artery Bypass Graft (CABG) surgery peri-operative pain
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased plasma methotrexate levels, leading to toxicity.
SSRIs and SNRIs
Increased risk of gastrointestinal bleeding.
Diuretics (e.g., Furosemide)
Reduced natriuretic effect and potential for renal toxicity.
Warfarin and other anticoagulants
Increased risk of bleeding.
ACE Inhibitors and Angiotensin Receptor Blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of the reach and sight of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, drowsiness, lethargy, tinnitus, and headache. In severe cases, gastrointestinal bleeding, acute renal failure, coma, and convulsions may occur. Management is primarily supportive; gastric lavage and activated charcoal may be considered if recent ingestion. Monitor vital signs and renal function.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to the risk of premature closure of the fetal ductus arteriosus and potential renal dysfunction in the fetus. Use with caution during the first and second trimesters and during lactation; only if the potential benefit justifies the potential risk to the fetus/infant. Consult a doctor.
Side Effects
Contraindications
- Known hypersensitivity to NSAIDs or any component of KX-100
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Severe uncontrolled heart failure
- Coronary Artery Bypass Graft (CABG) surgery peri-operative pain
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased plasma methotrexate levels, leading to toxicity.
SSRIs and SNRIs
Increased risk of gastrointestinal bleeding.
Diuretics (e.g., Furosemide)
Reduced natriuretic effect and potential for renal toxicity.
Warfarin and other anticoagulants
Increased risk of bleeding.
ACE Inhibitors and Angiotensin Receptor Blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of the reach and sight of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, drowsiness, lethargy, tinnitus, and headache. In severe cases, gastrointestinal bleeding, acute renal failure, coma, and convulsions may occur. Management is primarily supportive; gastric lavage and activated charcoal may be considered if recent ingestion. Monitor vital signs and renal function.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to the risk of premature closure of the fetal ductus arteriosus and potential renal dysfunction in the fetus. Use with caution during the first and second trimesters and during lactation; only if the potential benefit justifies the potential risk to the fetus/infant. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Expired
Clinical Trials
Extensive Phase III clinical trials have demonstrated the efficacy and safety of KX-100 in managing various chronic and acute pain conditions. Post-marketing surveillance and Phase IV studies are ongoing to further evaluate long-term outcomes and rare adverse events.
Lab Monitoring
- Complete Blood Count (CBC) for anemia and bleeding
- Liver Function Tests (LFTs) for hepatic toxicity
- Renal Function Tests (RFTs) including serum creatinine and BUN
- Blood pressure monitoring
Doctor Notes
- Advise patients to report any signs of gastrointestinal bleeding (e.g., black, tarry stools, severe abdominal pain) immediately.
- Exercise caution in patients with a history of hypertension, heart failure, or other cardiovascular risk factors, and monitor blood pressure regularly.
- Periodically assess renal function and liver enzymes with long-term use.
- Consider the lowest effective dose for the shortest possible duration.
- Educate patients on the black box warnings associated with NSAIDs.
Patient Guidelines
- Always take KX-100 with food or milk to minimize stomach upset.
- Do not exceed the recommended dose or duration of treatment without consulting your doctor.
- Inform your doctor about all other medications, herbal products, and supplements you are taking to avoid potential drug interactions.
- Report any unusual bleeding, persistent stomach pain, black or tarry stools, or swelling in ankles/feet to your doctor immediately.
- Do not drive or operate heavy machinery if you experience dizziness or drowsiness.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
KX-100 may cause dizziness, drowsiness, or visual disturbances in some individuals. If you experience these side effects, avoid driving or operating heavy machinery until you are sure you can perform such activities safely.
Lifestyle Advice
- Avoid alcohol consumption while taking this medicine as it can increase the risk of stomach bleeding.
- Maintain adequate hydration throughout the day.
- Engage in light exercise or physical therapy if pain permits and as advised by your healthcare provider.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.