Labenac SR
Generic Name
Diclofenac Sodium SR
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| labenac sr 200 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Labenac SR is a non-steroidal anti-inflammatory drug (NSAID) primarily used to alleviate pain and reduce inflammation in various conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute musculoskeletal disorders. Its sustained-release formulation ensures prolonged action.
Uses & Indications
Dosage
Adults
Typically one 100 mg SR tablet once daily, preferably with food.
Elderly
Lower doses or careful monitoring may be required, especially in those with renal or hepatic impairment.
Renal_impairment
Use with caution; dose reduction may be necessary. Avoid in severe renal impairment.
How to Take
Swallow the tablet whole with a glass of water, preferably with or after food to minimize gastrointestinal upset. Do not chew or crush.
Mechanism of Action
Diclofenac inhibits cyclooxygenase (COX-1 and COX-2) enzymes, leading to a reduction in prostaglandin synthesis, which are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Within 1-2 hours for pain relief, but full anti-inflammatory effects may take longer.
Excretion
Excreted mainly via urine (approx. 60%) and bile (approx. 30%) as metabolites.
Half life
Approximately 1-2 hours (terminal half-life), but its clinical effect lasts longer due to sustained release.
Absorption
Well absorbed orally, with SR formulation designed for sustained release over 24 hours.
Metabolism
Extensively metabolized in the liver, primarily by hydroxylation and glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to diclofenac or other NSAIDs
- Active gastrointestinal ulceration, bleeding, or perforation
- Severe heart failure
- Severe hepatic or renal impairment
- Third trimester of pregnancy
- Aspirin-induced asthma or urticaria
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding
Lithium
Increased lithium levels
Warfarin
Increased risk of bleeding
Diuretics
Reduced diuretic and antihypertensive effects
Methotrexate
Increased methotrexate toxicity
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management includes symptomatic and supportive care. Gastric lavage or activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of ductus arteriosus. Use with caution in first and second trimesters only if clearly needed and benefits outweigh risks. Diclofenac passes into breast milk in small amounts; use with caution or consider alternatives during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical data supporting efficacy and safety of diclofenac in various inflammatory and painful conditions.
Lab Monitoring
- Liver function tests (LFTs)
- Renal function tests (RFTs)
- Complete blood count (CBC)
- Blood pressure monitoring
Doctor Notes
- Educate patients on NSAID risks, especially GI and CV events, and the importance of taking with food.
- Monitor renal function, blood pressure, and liver enzymes during chronic therapy, especially in elderly patients or those with pre-existing conditions.
- Consider co-prescription of a proton pump inhibitor (PPI) for patients at high risk of GI complications.
Patient Guidelines
- Take with food to minimize stomach upset.
- Do not crush or chew the tablet.
- Report any signs of stomach bleeding (black stools, vomiting blood) immediately.
- Avoid alcohol during treatment.
- Do not exceed the prescribed dose.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness, drowsiness, or visual disturbances; exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a healthy diet and stay hydrated.
- Engage in light exercise if pain permits.
- Avoid smoking, as it can worsen GI side effects.
- Limit prolonged sun exposure.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.