Medicine Information

Lansopril

Name: Lansopril
Brand: Lansopril
Rating: 4.5 (117 reviews)

Capsule30 mgProton Pump Inhibitor (PPI)ATC: A02BC03

Generic Name

Lansopril 30 mg Capsule

Manufacturer

Various generic manufacturers worldwide

Country

Global (manufactured in many countries)

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
lansopril 30 mg capsule	৳ 5.50	N/A

Description

Overview of the medicine

Lansopril is a proton pump inhibitor (PPI) used to treat conditions involving excess stomach acid, such as gastroesophageal reflux disease (GERD), ulcers, and Zollinger-Ellison syndrome.

Uses & Indications

Gastroesophageal Reflux Disease (GERD)

Erosive Esophagitis

Duodenal Ulcers

Gastric Ulcers

Zollinger-Ellison Syndrome

H. pylori eradication (as part of a multi-drug regimen)

Dosage

Adults

Typical dose is 15 mg or 30 mg once daily, usually before breakfast. Duration varies by condition (e.g., GERD 4-8 weeks, Ulcers 2-4 weeks).

Elderly

No specific dosage adjustment required, but monitor for adverse effects, especially in patients with severe hepatic impairment.

Renal_impairment

No dosage adjustment needed for renal impairment. Caution with severe hepatic impairment.

How to Take

Take orally, usually once daily before a meal. Do not chew or crush the capsule; swallow whole.

Mechanism of Action

Lansopril irreversibly binds to and inhibits the H+/K+-ATPase pump (proton pump) in the gastric parietal cells, thereby suppressing gastric acid secretion.

Pharmacokinetics

Onset

Acid secretion inhibition begins within 1-2 hours, full effect within a few days.

Excretion

Primarily excreted in the feces (approximately two-thirds) and urine (approximately one-third) as metabolites.

Half life

Plasma elimination half-life is 1.5-2 hours, but its acid-suppressing effect is much longer.

Absorption

Rapidly absorbed after oral administration, bioavailability is approximately 80-90%.

Metabolism

Extensively metabolized in the liver by the cytochrome P450 enzyme system, primarily CYP2C19 and CYP3A4.

Side Effects

Contraindications

Hypersensitivity to lansopril or any component of the formulation.
Concomitant use with rilpivirine-containing products.

Drug Interactions

Digoxin

May increase digoxin levels.

Warfarin

May increase INR and risk of bleeding.

Clopidogrel

May reduce the antiplatelet effect of clopidogrel.

Methotrexate

May increase methotrexate levels and toxicity.

Atazanavir, Nelfinavir, Rilpivirine

Reduced absorption, potentially leading to loss of virologic response.

Iron Salts, Ketoconazole, Itraconazole

Reduced absorption due to increased gastric pH.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Experience with overdose is limited. Symptomatic and supportive treatment is recommended. Lansopril is not significantly removed by hemodialysis.

Pregnancy & Lactation

Pregnancy Category B. Use only if clearly needed during pregnancy. Caution is advised during lactation; consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules20 capsules30 capsules50 capsules

Shelf Life

Typically 2-3 years from the date of manufacture, check expiry date on packaging.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by regulatory bodies (e.g., FDA, DGDA)

Patent Status

Patent expired, available as generic

WHO Essential Medicine

Yes

Clinical Trials

Lansopril has undergone extensive clinical trials demonstrating its efficacy and safety in various acid-related disorders.

Lab Monitoring

Monitor magnesium levels in patients on long-term therapy or with concomitant medications.
Consider Vitamin B12 levels during prolonged use (over 3 years).

Doctor Notes

Use the lowest effective dose for the shortest duration necessary.
Consider magnesium supplementation for long-term PPI users.
Educate patients on potential long-term risks, including bone health and C. difficile.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Swallow the capsule whole; do not chew, crush, or open it.
Take it before a meal, preferably in the morning.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.