Lansopril
Generic Name
Lansopril 30 mg Capsule
Manufacturer
Various generic manufacturers worldwide
Country
Global (manufactured in many countries)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lansopril 30 mg capsule | ৳ 5.50 | N/A |
Description
Overview of the medicine
Lansopril is a proton pump inhibitor (PPI) used to treat conditions involving excess stomach acid, such as gastroesophageal reflux disease (GERD), ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
Typical dose is 15 mg or 30 mg once daily, usually before breakfast. Duration varies by condition (e.g., GERD 4-8 weeks, Ulcers 2-4 weeks).
Elderly
No specific dosage adjustment required, but monitor for adverse effects, especially in patients with severe hepatic impairment.
Renal_impairment
No dosage adjustment needed for renal impairment. Caution with severe hepatic impairment.
How to Take
Take orally, usually once daily before a meal. Do not chew or crush the capsule; swallow whole.
Mechanism of Action
Lansopril irreversibly binds to and inhibits the H+/K+-ATPase pump (proton pump) in the gastric parietal cells, thereby suppressing gastric acid secretion.
Pharmacokinetics
Onset
Acid secretion inhibition begins within 1-2 hours, full effect within a few days.
Excretion
Primarily excreted in the feces (approximately two-thirds) and urine (approximately one-third) as metabolites.
Half life
Plasma elimination half-life is 1.5-2 hours, but its acid-suppressing effect is much longer.
Absorption
Rapidly absorbed after oral administration, bioavailability is approximately 80-90%.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 enzyme system, primarily CYP2C19 and CYP3A4.
Side Effects
Contraindications
- •Hypersensitivity to lansopril or any component of the formulation.
- •Concomitant use with rilpivirine-containing products.
Drug Interactions
Digoxin
May increase digoxin levels.
Warfarin
May increase INR and risk of bleeding.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel.
Methotrexate
May increase methotrexate levels and toxicity.
Atazanavir, Nelfinavir, Rilpivirine
Reduced absorption, potentially leading to loss of virologic response.
Iron Salts, Ketoconazole, Itraconazole
Reduced absorption due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Experience with overdose is limited. Symptomatic and supportive treatment is recommended. Lansopril is not significantly removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed during pregnancy. Caution is advised during lactation; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, check expiry date on packaging.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Patent expired, available as generic
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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