Laxocon
Generic Name
Sodium Picosulfate
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| laxocon 10 mg tablet | ৳ 12.00 | ৳ 120.00 |
| laxocon 5 mg oral solution | ৳ 85.00 | N/A |
Description
Overview of the medicine
Laxocon contains Sodium Picosulfate, a stimulant laxative used for the short-term treatment of constipation and for bowel preparation before medical procedures.
Uses & Indications
Dosage
Adults
5-10 mg once daily at bedtime.
Elderly
Start with lower dose, 5 mg once daily, adjust as needed.
Renal_impairment
No specific dosage adjustment required, but use with caution.
How to Take
Take orally, preferably at bedtime with water. Do not chew or crush tablets.
Mechanism of Action
Sodium Picosulfate is a prodrug that is activated by bacterial enzymes in the colon to form bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM). BHPM stimulates colonic peristalsis and increases water and electrolyte secretion into the intestinal lumen, leading to laxative action.
Pharmacokinetics
Onset
6-12 hours
Excretion
Primarily fecal excretion of active metabolite; small amount excreted renally.
Half life
Not directly applicable for active metabolite due to local action; plasma half-life of parent compound is short.
Absorption
Minimal systemic absorption of the prodrug; converted to active metabolite (BHPM) in the colon.
Metabolism
Converted by colonic bacteria to BHPM, then enterohepatic recirculation of BHPM.
Side Effects
Contraindications
- Hypersensitivity to Sodium Picosulfate or any excipients
- Acute abdominal conditions (e.g., appendicitis, severe dehydration)
- Intestinal obstruction
- Severe abdominal pain with nausea and vomiting
Drug Interactions
Antibiotics
May reduce laxative effect by altering gut flora.
Cardiac glycosides
Increased sensitivity to glycosides due to hypokalemia.
Diuretics, corticosteroids
May increase risk of electrolyte imbalance (hypokalemia).
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include severe abdominal cramps, diarrhea, and significant fluid and electrolyte loss. Management involves supportive care, fluid and electrolyte replacement.
Pregnancy & Lactation
Generally not recommended during pregnancy or lactation unless clearly necessary and advised by a doctor. Limited human data.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, supermarkets
Approval Status
Approved by regulatory bodies
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of Sodium Picosulfate in treating constipation and for bowel preparation.
Lab Monitoring
- Electrolyte levels (in prolonged use or high doses)
Doctor Notes
- Emphasize short-term use and hydration.
- Advise patients on lifestyle modifications for chronic constipation.
- Monitor electrolytes in vulnerable patients.
Patient Guidelines
- Do not use for more than 7 consecutive days without consulting a doctor.
- Drink plenty of fluids while using this medicine.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it's close to the next scheduled dose, skip the missed dose and resume your regular schedule. Do not double the dose.
Driving Precautions
Laxocon generally does not affect the ability to drive or operate machinery. However, if dizziness occurs, avoid such activities.
Lifestyle Advice
- Maintain a high-fiber diet.
- Engage in regular physical activity.
- Ensure adequate fluid intake.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.