Lefex
Generic Name
Levofloxacin
Manufacturer
Square Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lefex 500 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Levofloxacin is a synthetic broad-spectrum antibacterial agent of the fluoroquinolone class. It is used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
500 mg once daily for 7-14 days depending on the infection.
Elderly
No specific dosage adjustment usually required unless renal impairment is present.
Renal_impairment
Dosage adjustment is required based on creatinine clearance.
How to Take
Orally, with or without food. Should be swallowed whole with water.
Mechanism of Action
Inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes for DNA replication, transcription, repair, and recombination.
Pharmacokinetics
Onset
Varies by infection, typically within hours to days.
Excretion
Primarily excreted unchanged in the urine.
Half life
Approximately 6-8 hours.
Absorption
Rapid and complete absorption after oral administration; peak plasma concentrations reached within 1-2 hours.
Metabolism
Minimally metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to levofloxacin or other fluoroquinolones
- Epilepsy
- History of tendon disorders related to fluoroquinolone administration
Drug Interactions
NSAIDs
May increase the risk of CNS stimulation and convulsive seizures.
Warfarin
May enhance the anticoagulant effects of warfarin.
Antacids (containing magnesium, aluminum), Sucralfate, Iron supplements
Can decrease levofloxacin absorption.
Storage
Store below 30°C in a dry place, away from light.
Overdose
Gastric lavage and symptomatic treatment. No specific antidote.
Pregnancy & Lactation
Generally not recommended during pregnancy or lactation unless essential, due to potential risks to fetal cartilage development. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to levofloxacin or other fluoroquinolones
- Epilepsy
- History of tendon disorders related to fluoroquinolone administration
Drug Interactions
NSAIDs
May increase the risk of CNS stimulation and convulsive seizures.
Warfarin
May enhance the anticoagulant effects of warfarin.
Antacids (containing magnesium, aluminum), Sucralfate, Iron supplements
Can decrease levofloxacin absorption.
Storage
Store below 30°C in a dry place, away from light.
Overdose
Gastric lavage and symptomatic treatment. No specific antidote.
Pregnancy & Lactation
Generally not recommended during pregnancy or lactation unless essential, due to potential risks to fetal cartilage development. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support its efficacy and safety profile for approved indications.
Lab Monitoring
- Renal function in patients with impairment
- Blood glucose in diabetic patients
- Prothrombin time/INR in patients on warfarin
Doctor Notes
- Assess for risk factors of tendinopathy, particularly in elderly or those on corticosteroids.
- Monitor for QT prolongation.
- Counsel patients on potential peripheral neuropathy symptoms.
Patient Guidelines
- Complete the full course of medication even if symptoms improve
- Avoid excessive sun exposure
- Report any joint pain or unusual sensations
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose.
Driving Precautions
May cause dizziness or visual disturbances; advise caution when driving or operating machinery.
Lifestyle Advice
- Maintain good hydration
- Avoid driving or operating machinery if dizziness occurs
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.