Leokast
Generic Name
Montelukast
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| leokast 10 mg tablet | ৳ 14.00 | ৳ 140.00 |
Description
Overview of the medicine
Leokast 10 mg Tablet contains Montelukast, a leukotriene receptor antagonist. It is used to prevent and treat chronic asthma, allergic rhinitis (hay fever), and exercise-induced bronchoconstriction.
Uses & Indications
Dosage
Adults
10 mg once daily, taken in the evening.
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment.
Hepatic_impairment
No dosage adjustment is necessary for patients with mild to moderate hepatic impairment. Patients with severe hepatic impairment have not been studied.
How to Take
Leokast 10 mg Tablet should be taken orally once daily in the evening, with or without food. It is important to continue taking this medicine regularly, even if you feel well.
Mechanism of Action
Montelukast selectively antagonizes the CysLT1 receptor, blocking the action of leukotrienes D4, E4, and C4. Leukotrienes are potent inflammatory mediators that cause bronchoconstriction, mucus secretion, and increased vascular permeability, contributing to the symptoms of asthma and allergic rhinitis.
Pharmacokinetics
Onset
Clinical effects are typically observed within one day of starting treatment for asthma.
Excretion
Primarily excreted via bile into feces (approximately 86%); less than 0.2% is excreted in urine.
Half life
Plasma half-life ranges from 2.7 to 5.5 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in 2-4 hours.
Metabolism
Extensively metabolized by cytochrome P450 enzymes (CYP3A4, CYP2C8, and CYP2C9) in the liver.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any of its components.
Drug Interactions
Rifampicin
May decrease the plasma concentration of Montelukast, requiring careful monitoring.
Phenobarbital
May decrease the plasma concentration of Montelukast, requiring careful monitoring.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In cases of overdose, common adverse events included abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Montelukast should be used during pregnancy only if clearly needed. It is unknown whether Montelukast is excreted in human milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any of its components.
Drug Interactions
Rifampicin
May decrease the plasma concentration of Montelukast, requiring careful monitoring.
Phenobarbital
May decrease the plasma concentration of Montelukast, requiring careful monitoring.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In cases of overdose, common adverse events included abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Montelukast should be used during pregnancy only if clearly needed. It is unknown whether Montelukast is excreted in human milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Refer to the expiry date on the packaging, typically 2-3 years from manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent expired for generic forms (original patent held by Merck for Singulair)
Clinical Trials
Montelukast has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of asthma and allergic rhinitis across various age groups.
Lab Monitoring
- Routine laboratory monitoring is generally not required for Montelukast.
Doctor Notes
- Advise patients about potential neuropsychiatric symptoms and to report any changes immediately.
- Emphasize that Montelukast is for maintenance therapy, not for acute bronchospasm.
- Consider alternative therapies if patients experience significant neuropsychiatric adverse effects.
Patient Guidelines
- Take this medicine every day as prescribed, even if you feel well.
- This medicine is not for immediate relief of acute asthma attacks; use a fast-acting inhaler for rescue.
- Do not stop taking Montelukast without consulting your doctor.
- Report any mood or behavior changes to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not take a double dose to make up for a missed one.
Driving Precautions
Montelukast may cause dizziness or somnolence in some patients. Patients should be advised to exercise caution before driving or operating machinery until they know how Montelukast affects them.
Lifestyle Advice
- Identify and avoid asthma triggers (e.g., allergens, irritants).
- Maintain a healthy lifestyle with regular exercise, but be aware of exercise-induced bronchoconstriction if susceptible.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.