Levemir FlexPen
Generic Name
Insulin Detemir
Manufacturer
Novo Nordisk
Country
Denmark
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| levemir flexpen 100 iu injection | ৳ 1,600.00 | N/A |
Description
Overview of the medicine
Insulin detemir is a long-acting insulin analog used to control high blood sugar in adults and children with diabetes mellitus. It provides a relatively constant glucose-lowering effect for up to 24 hours.
Uses & Indications
Dosage
Adults
Individualized based on patient's metabolic needs, blood glucose monitoring results, and glycemic control goal. Typically administered once or twice daily.
Elderly
Initiate with a lower dose and monitor closely due to potential for hypoglycemia and age-related decline in renal/hepatic function.
Renal_impairment
Dose reduction may be required. Monitor blood glucose closely.
How to Take
Administer subcutaneously once or twice daily at the same time(s) each day. Rotate injection sites within the same region (e.g., abdomen, thigh, upper arm). Do not administer intravenously or intramuscularly.
Mechanism of Action
Lowers blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin inhibits lipolysis and proteolysis, and enhances protein synthesis.
Pharmacokinetics
Onset
1-2 hours
Excretion
Primarily renal excretion of metabolites.
Half life
Approximately 5-9 hours, depending on dose and individual.
Absorption
Slow and protracted absorption from subcutaneous tissue due to multihexamer formation and reversible albumin binding.
Metabolism
Degraded by insulin-degrading enzymes similar to human insulin.
Side Effects
Contraindications
- During episodes of hypoglycemia.
- Hypersensitivity to insulin detemir or any of its excipients.
Drug Interactions
Beta-blockers
Mask symptoms of hypoglycemia and delay recovery.
Corticosteroids, Diuretics, Sympathomimetics
Decreased insulin effect, increased blood glucose.
Oral antidiabetic agents, ACE inhibitors, Aspirin
Increased risk of hypoglycemia.
Storage
Unopened: Store in refrigerator (2°C-8°C). Do not freeze. Opened/In-use: Store at room temperature (below 30°C) for up to 42 days. Protect from light and heat.
Overdose
Overdose can lead to severe hypoglycemia, which may be treated by oral glucose or intravenous glucose or glucagon depending on severity.
Pregnancy & Lactation
Use during pregnancy should be carefully considered, only if clearly needed. Insulin requirements may change during pregnancy and lactation.
Side Effects
Contraindications
- During episodes of hypoglycemia.
- Hypersensitivity to insulin detemir or any of its excipients.
Drug Interactions
Beta-blockers
Mask symptoms of hypoglycemia and delay recovery.
Corticosteroids, Diuretics, Sympathomimetics
Decreased insulin effect, increased blood glucose.
Oral antidiabetic agents, ACE inhibitors, Aspirin
Increased risk of hypoglycemia.
Storage
Unopened: Store in refrigerator (2°C-8°C). Do not freeze. Opened/In-use: Store at room temperature (below 30°C) for up to 42 days. Protect from light and heat.
Overdose
Overdose can lead to severe hypoglycemia, which may be treated by oral glucose or intravenous glucose or glucagon depending on severity.
Pregnancy & Lactation
Use during pregnancy should be carefully considered, only if clearly needed. Insulin requirements may change during pregnancy and lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Varies by region, typically 2-3 years for unopened, refrigerated pens.
Availability
Pharmacies, hospitals
Approval Status
FDA Approved
Patent Status
Patent expired in many regions
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of insulin detemir in both type 1 and type 2 diabetes.
Lab Monitoring
- Blood glucose levels (fasting, pre-meal, post-meal, bedtime).
- HbA1c (glycated hemoglobin) every 3-6 months.
- Potassium levels (in patients at risk of hypokalemia).
Doctor Notes
- Emphasize patient education on hypoglycemia recognition and management.
- Regular blood glucose monitoring is crucial for dose adjustment.
- Educate on proper storage and handling of the FlexPen.
Patient Guidelines
- Always check the insulin label before each injection.
- Learn proper injection technique and site rotation.
- Carry identification indicating diabetes.
- Do not share pens or needles.
Missed Dose Advice
If a dose is missed, patients should monitor their blood glucose and contact their healthcare provider for advice. Do not take a double dose to make up for a missed dose.
Driving Precautions
Patients should be aware of the risk of hypoglycemia and its symptoms, which may impair the ability to drive or operate machinery.
Lifestyle Advice
- Follow a balanced diet and regular exercise regimen.
- Monitor blood glucose regularly as advised by your doctor.
- Maintain a healthy weight.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.