Levoday
Generic Name
Levofloxacin
Manufacturer
ACI Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| levoday 500 mg tablet | ৳ 16.00 | ৳ 160.00 |
Description
Overview of the medicine
Levoday 500 mg Tablet contains Levofloxacin, a synthetic broad-spectrum antibacterial agent of the fluoroquinolone class, used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
Usually 500 mg once daily for 7-14 days depending on the infection. For some severe infections, 750 mg once daily may be used.
Elderly
No specific dose adjustment is required based on age alone, but renal function should be assessed.
Renal_impairment
Dosage adjustment is necessary for patients with creatinine clearance <50 mL/min. For example, 500 mg initial dose, then 250 mg every 24-48 hours depending on creatinine clearance.
How to Take
Take orally with or without food. Do not take with antacids containing magnesium or aluminum, sucralfate, iron, or zinc supplements; administer at least 2 hours before or 2 hours after these agents.
Mechanism of Action
Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination, thereby leading to bacterial cell death.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 1-2 hours after oral administration.
Excretion
Primarily excreted unchanged in the urine, mainly through glomerular filtration and tubular secretion.
Half life
Approximately 6-8 hours, allowing for once-daily dosing.
Absorption
Rapid and complete oral absorption, bioavailability approximately 99%.
Metabolism
Minimally metabolized in the liver (less than 5% of a dose).
Side Effects
Contraindications
- Hypersensitivity to levofloxacin, other quinolones, or any component of the formulation.
- History of tendinitis or tendon rupture associated with fluoroquinolone use.
- Epilepsy or other seizure disorders.
Drug Interactions
NSAIDs
May increase the risk of CNS stimulation and convulsive seizures.
Warfarin
May enhance the anticoagulant effect of warfarin, increasing bleeding risk.
Corticosteroids
Increased risk of tendinopathy and tendon rupture.
Antacids (Mg/Al), Sucralfate, Iron/Zinc supplements
Reduce oral absorption of levofloxacin.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include CNS effects (confusion, dizziness, seizures), QT prolongation. Treatment is symptomatic and supportive. Gastric lavage and adequate hydration may be helpful. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category C. Not recommended for use during pregnancy or lactation due to potential risks to the fetus/infant, including cartilage damage.
Side Effects
Contraindications
- Hypersensitivity to levofloxacin, other quinolones, or any component of the formulation.
- History of tendinitis or tendon rupture associated with fluoroquinolone use.
- Epilepsy or other seizure disorders.
Drug Interactions
NSAIDs
May increase the risk of CNS stimulation and convulsive seizures.
Warfarin
May enhance the anticoagulant effect of warfarin, increasing bleeding risk.
Corticosteroids
Increased risk of tendinopathy and tendon rupture.
Antacids (Mg/Al), Sucralfate, Iron/Zinc supplements
Reduce oral absorption of levofloxacin.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include CNS effects (confusion, dizziness, seizures), QT prolongation. Treatment is symptomatic and supportive. Gastric lavage and adequate hydration may be helpful. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category C. Not recommended for use during pregnancy or lactation due to potential risks to the fetus/infant, including cartilage damage.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from manufacturing date
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by regulatory bodies (e.g., DGDA, FDA)
Patent Status
Generic available, patent expired for the active ingredient
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of levofloxacin for its approved indications.
Lab Monitoring
- Renal function tests (creatinine, BUN)
- Blood glucose (especially in diabetic patients)
- Liver function tests (if indicated)
- ECG monitoring (for patients at risk of QT prolongation)
Doctor Notes
- Use with caution in elderly patients, those with renal impairment, and patients at risk for QT prolongation.
- Advise patients to report any signs of tendinitis, peripheral neuropathy, or CNS effects immediately.
- Avoid concomitant use with multivalent cations (e.g., antacids, iron, zinc) to prevent reduced absorption.
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve.
- Avoid excessive exposure to sunlight or artificial UV light, as it may cause photosensitivity.
- Report any tendon pain, swelling, or inflammation immediately to your doctor.
- Stay well-hydrated during treatment.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Levofloxacin may cause dizziness, lightheadedness, or visual disturbances. Patients should exercise caution when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Avoid prolonged sun exposure and use sunscreen.
- Diabetic patients should monitor their blood glucose levels closely.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.