Levomax-TS
Generic Name
levomax-ts-15-eye-drop
Manufacturer
PharmaCorp Bangladesh
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| levomax ts 15 eye drop | ৳ 130.00 | N/A |
Description
Overview of the medicine
Levomax-TS 0.5% Eye Drop is an antibiotic medication containing Levofloxacin, a fluoroquinolone antibiotic. It is used to treat bacterial infections of the eye, such as bacterial conjunctivitis and corneal ulcers, by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
For bacterial conjunctivitis: Instill 1-2 drops into the affected eye(s) every 2 hours while awake, up to 8 times a day, for the first 2 days. Then, 1-2 drops every 4 hours while awake, up to 4 times a day, for the next 5 days or as directed by physician. For corneal ulcers: Instill 1-2 drops into the affected eye(s) every 15-30 minutes for the first few hours, then every 1 hour, then gradually reduce frequency over 7-14 days.
Elderly
No specific dosage adjustment is generally required for elderly patients.
Renal_impairment
No specific dosage adjustment is necessary for ophthalmic use as systemic absorption is minimal.
How to Take
For ophthalmic use only. Wash hands thoroughly before administration. Tilt head back, pull down the lower eyelid to form a pouch, instill the drops into the pouch, and gently close the eye for a few minutes. Avoid touching the dropper tip to any surface (eye, finger, or other) to prevent contamination. If more than one ophthalmic medication is used, wait at least 5 minutes between applications to ensure proper absorption.
Mechanism of Action
Levofloxacin, a third-generation fluoroquinolone, inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV. These enzymes are crucial for bacterial DNA replication, transcription, repair, and recombination. By inhibiting them, Levofloxacin causes bacterial cell death, thus exerting its bactericidal effect.
Pharmacokinetics
Onset
Within hours of administration, with symptomatic improvement typically observed within 2-5 days.
Excretion
Primarily excreted unchanged in urine following systemic absorption, but locally in tears and ocular surface.
Half life
Plasma half-life is approximately 6-8 hours, but ocular tissue half-life varies. Excretion from ocular surface is rapid.
Absorption
Following topical ophthalmic administration, levofloxacin is absorbed into the ocular tissues. Systemic absorption is minimal.
Metabolism
Minimally metabolized. Less than 5% of an orally administered dose is metabolized.
Side Effects
Contraindications
- Hypersensitivity to Levofloxacin, other quinolones, or any component of the formulation.
Drug Interactions
Systemic Quinolones
Although systemic absorption is minimal with topical ophthalmic use, theoretical additive effects with systemic quinolones are possible but not clinically significant under normal usage.
Other Ophthalmic Medications
If using other eye drops, administer them at least 5 minutes apart to avoid washout and ensure adequate drug contact time with the eye.
Storage
Store at controlled room temperature (20°C to 25°C), excursions permitted to 15°C to 30°C. Protect from light. Do not freeze. Keep the bottle tightly closed when not in use.
Overdose
Overdose is unlikely with topical ophthalmic administration. If an accidental overdose occurs, flush the eye with lukewarm water. Symptomatic treatment may be initiated if necessary.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when Levomax-TS 0.5% Eye Drop is administered to a nursing woman, as it is not known whether levofloxacin is excreted in human milk after ophthalmic use.
Side Effects
Contraindications
- Hypersensitivity to Levofloxacin, other quinolones, or any component of the formulation.
Drug Interactions
Systemic Quinolones
Although systemic absorption is minimal with topical ophthalmic use, theoretical additive effects with systemic quinolones are possible but not clinically significant under normal usage.
Other Ophthalmic Medications
If using other eye drops, administer them at least 5 minutes apart to avoid washout and ensure adequate drug contact time with the eye.
Storage
Store at controlled room temperature (20°C to 25°C), excursions permitted to 15°C to 30°C. Protect from light. Do not freeze. Keep the bottle tightly closed when not in use.
Overdose
Overdose is unlikely with topical ophthalmic administration. If an accidental overdose occurs, flush the eye with lukewarm water. Symptomatic treatment may be initiated if necessary.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when Levomax-TS 0.5% Eye Drop is administered to a nursing woman, as it is not known whether levofloxacin is excreted in human milk after ophthalmic use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months (unopened). Discard 28 days after opening.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of levofloxacin ophthalmic solution for treating bacterial ocular infections, showing high rates of clinical and microbiological cure against common pathogens.
Lab Monitoring
- No routine lab monitoring is required for topical ophthalmic Levofloxacin due to minimal systemic absorption.
Doctor Notes
- Advise patients not to wear contact lenses during the acute phase of infection or while on treatment unless medically necessary.
- Educate patients on proper administration technique to minimize contamination and ensure effective treatment.
- Monitor for signs of superinfection, especially fungal, if treatment is prolonged or symptoms worsen.
- In cases of severe infections like corneal ulcers, frequent dosing is crucial initially.
Patient Guidelines
- Complete the full course of treatment as prescribed by your doctor, even if symptoms improve or disappear.
- Do not wear contact lenses during treatment for eye infections unless specifically advised by your doctor.
- Avoid contaminating the dropper tip with your eye, hands, or any other surface.
- Inform your doctor if your condition worsens or does not improve after a few days of treatment.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
This medication may cause temporary blurred vision or other visual disturbances immediately after administration. If you experience blurred vision or dizziness, avoid driving or operating machinery until your vision is clear and your symptoms have subsided.
Lifestyle Advice
- Maintain good eye hygiene to prevent further infection.
- Avoid rubbing your eyes, especially during an infection.
- Wash hands frequently, particularly before and after touching your eyes or applying medication.
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