Levomet
Generic Name
Levofloxacin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| levomet 250 mg tablet | ৳ 8.00 | N/A |
Description
Overview of the medicine
Levomet is a brand name for Levofloxacin, a synthetic broad-spectrum antibacterial agent of the fluoroquinolone class. It is used to treat a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
Typically 500 mg once daily for 7-14 days, depending on the infection type and severity. For some severe infections, 750 mg once daily.
Elderly
No dose adjustment required based on age alone, but renal function should be assessed.
Renal_impairment
Dosage adjustment is necessary for patients with creatinine clearance < 50 mL/min.
How to Take
Levomet tablets can be taken orally with or without food. It should be taken with a full glass of water. Do not crush or chew the tablet.
Mechanism of Action
Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Antibacterial effect typically observed within hours of first dose.
Excretion
Primarily excreted unchanged in the urine, mainly by glomerular filtration and tubular secretion.
Half life
Approximately 6-8 hours, allowing for once-daily dosing.
Absorption
Rapid and nearly complete oral absorption, with peak plasma concentrations achieved within 1-2 hours.
Metabolism
Minimally metabolized in the liver; approximately 5% of a dose is metabolized.
Side Effects
Contraindications
- Hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the formulation
- History of tendon disorders related to fluoroquinolone administration
- Epilepsy or other seizure disorders
Drug Interactions
0
Antacids containing magnesium or aluminum, sucralfate, metal cations (iron, zinc): May reduce absorption of levofloxacin. Administer levofloxacin at least 2 hours before or 2 hours after these agents.
1
Warfarin: May enhance the anticoagulant effects of warfarin. Monitor INR.
2
Corticosteroids: Concomitant use increases the risk of tendon disorders.
3
NSAIDs: May increase the risk of CNS stimulation and convulsive seizures.
4
Anti-arrhythmic drugs (e.g., Class IA and III antiarrhythmics, tricyclic antidepressants): Increased risk of QT prolongation.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
In the event of an acute overdose, the stomach should be emptied. The patient should be observed and given symptomatic and supportive treatment. Hydration should be maintained. Hemodialysis or peritoneal dialysis is not effective in removing levofloxacin from the body.
Pregnancy & Lactation
Pregnancy Category C. Levofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the formulation
- History of tendon disorders related to fluoroquinolone administration
- Epilepsy or other seizure disorders
Drug Interactions
0
Antacids containing magnesium or aluminum, sucralfate, metal cations (iron, zinc): May reduce absorption of levofloxacin. Administer levofloxacin at least 2 hours before or 2 hours after these agents.
1
Warfarin: May enhance the anticoagulant effects of warfarin. Monitor INR.
2
Corticosteroids: Concomitant use increases the risk of tendon disorders.
3
NSAIDs: May increase the risk of CNS stimulation and convulsive seizures.
4
Anti-arrhythmic drugs (e.g., Class IA and III antiarrhythmics, tricyclic antidepressants): Increased risk of QT prolongation.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
In the event of an acute overdose, the stomach should be emptied. The patient should be observed and given symptomatic and supportive treatment. Hydration should be maintained. Hemodialysis or peritoneal dialysis is not effective in removing levofloxacin from the body.
Pregnancy & Lactation
Pregnancy Category C. Levofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, consult packaging for exact date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent expired for generic Levofloxacin
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated Levofloxacin's efficacy and safety in various bacterial infections, leading to its widespread approval and use globally. Post-market surveillance continues to monitor for rare adverse events.
Lab Monitoring
- Liver function tests (LFTs) if prolonged treatment or liver impairment is suspected
- Renal function tests, especially in elderly or renally impaired patients
- Blood glucose monitoring in diabetic patients due to risk of dysglycemia
Doctor Notes
- Prescribe with caution in elderly patients, those with a history of tendon disorders, or concomitant corticosteroid use.
- Monitor for signs of hypersensitivity reactions, neurological symptoms, and cardiac arrhythmias.
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve, to prevent resistance.
- Stay well-hydrated throughout the treatment period.
- Avoid excessive exposure to sunlight or artificial UV light, and use protective clothing/sunscreen.
- Report any signs of tendon pain, swelling, or inflammation immediately to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Levomet may cause dizziness, lightheadedness, or visual disturbances. Patients should be advised not to drive or operate machinery if they experience these effects.
Lifestyle Advice
- Avoid consuming alcohol during treatment, as it may exacerbate side effects. Maintain a balanced diet and regular sleep schedule to support recovery.
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