Medicine Information

Levotiz

Name: Levotiz
Brand: Levotiz
Rating: 4.5 (117 reviews)

Tablet5 mgAntihistaminesATC: R06AE09

Generic Name

Levocetirizine

Manufacturer

Acme Laboratories Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
levotiz 5 mg tablet	৳ 2.50	৳ 25.00

Description

Overview of the medicine

Levotiz 5 mg Tablet contains Levocetirizine, a potent antihistamine used to relieve symptoms associated with allergic conditions such as hay fever, chronic urticaria, and allergic rhinitis.

Uses & Indications

Relief of symptoms associated with allergic rhinitis (including perennial allergic rhinitis)

Treatment of uncomplicated skin manifestations of chronic idiopathic urticaria

Symptomatic relief of pruritus and urticaria in allergic skin conditions

Dosage

Adults

Adults and adolescents 12 years and older: 5 mg once daily in the evening.

Elderly

Dosage adjustment may be necessary in elderly patients with impaired renal function.

Renal_impairment

Mild renal impairment: 2.5 mg once daily. Moderate renal impairment: 2.5 mg every other day. Severe renal impairment: Contraindicated.

How to Take

Levotiz 5 mg Tablet should be taken orally with or without food, preferably in the evening. Swallow the tablet whole with water.

Mechanism of Action

Levocetirizine is a potent, selective, peripheral H1-receptor antagonist. It blocks the action of histamine, a natural substance in the body that causes allergic symptoms, thereby alleviating itching, sneezing, watery eyes, and runny nose.

Pharmacokinetics

Onset

Within 15-30 minutes

Excretion

Primarily excreted unchanged in the urine (about 85%) and feces (about 13%).

Half life

Approximately 7-10 hours

Absorption

Rapidly and extensively absorbed from the gastrointestinal tract after oral administration.

Metabolism

Minimally metabolized in the liver (less than 14% of the dose).

Side Effects

Contraindications

Hypersensitivity to levocetirizine, cetirizine, or any piperazine derivative
Patients with severe renal impairment (creatinine clearance less than 10 mL/min)
Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption

Drug Interactions

Alcohol

Concurrent use with alcohol may further decrease alertness and impair central nervous system performance.

Ritonavir

May increase plasma concentration of levocetirizine.

CNS Depressants

Concurrent use with other CNS depressants (e.g., sedatives, tranquilizers) may increase the risk of CNS depression.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms may include drowsiness in adults and agitation or restlessness followed by drowsiness in children. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered shortly after ingestion.

Pregnancy & Lactation

Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, so caution is advised during breastfeeding.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per blister30 tablets per box

Shelf Life

Typically 24-36 months from manufacturing date.

Availability

Pharmacies, hospitals, clinics

Approval Status

Approved by regulatory bodies (e.g., FDA, DGDA)

Patent Status

Off-patent

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of levocetirizine for allergic conditions, including studies showing its rapid onset of action and sustained 24-hour symptom relief with a favorable safety profile.

Lab Monitoring

Renal function tests (creatinine clearance) in patients with kidney impairment.

Doctor Notes

Advise patients to take this medication in the evening to minimize daytime drowsiness.
Caution in patients with epilepsy due to potential for convulsions, though rare.
Adjust dose in renal impairment to avoid accumulation.

Patient Guidelines

Take as directed by your doctor, preferably in the evening.
Do not exceed the recommended dose.
Avoid alcohol while taking this medicine.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

May cause drowsiness; patients should be advised to exercise caution when driving or operating machinery until they know how they react to the medication.