Lexa
Generic Name
Escitalopram
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lexa 500 mg tablet | ৳ 15.00 | N/A |
Description
Overview of the medicine
Lexa (Escitalopram) is an antidepressant medication primarily used to treat major depressive disorder and generalized anxiety disorder. It works by restoring the balance of a natural substance (serotonin) in the brain.
Uses & Indications
Dosage
Adults
Major Depressive Disorder and Generalized Anxiety Disorder: Initial dose 10 mg once daily, may be increased to a maximum of 20 mg once daily after at least one week. Panic Disorder, Social Anxiety Disorder, OCD: Initial dose 5 mg once daily, may be increased to 10 mg after one week, maximum 20 mg once daily.
Elderly
Recommended initial dose 5 mg once daily, maximum 10 mg once daily.
Renal_impairment
No dosage adjustment needed for mild to moderate impairment. Use with caution in severe renal impairment.
How to Take
Take orally once daily with or without food. Swallow the tablet whole; do not chew, crush, or break.
Mechanism of Action
Escitalopram selectively inhibits the reuptake of serotonin (5-HT) in the brain, thereby increasing the concentration of serotonin in the synaptic cleft. This leads to enhanced serotonergic neurotransmission.
Pharmacokinetics
Onset
Initial effects may be seen in 1-2 weeks, full antidepressant effect in 4-6 weeks.
Excretion
Primarily via urine as metabolites.
Half life
Approximately 27-32 hours.
Absorption
Well absorbed orally, peak plasma concentrations reached in about 3-4 hours.
Metabolism
Extensively metabolized in the liver by CYP2C19, CYP3A4, and CYP2D6 enzymes to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to escitalopram or citalopram.
- Concomitant use of Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI, or starting an MAOI within 14 days of discontinuing escitalopram.
- Congenital long QT syndrome or concomitant use with other QT-prolonging medicinal products.
Drug Interactions
MAOIs
Risk of serious, sometimes fatal, reactions including serotonin syndrome.
Triptans
Increased risk of serotonin syndrome.
NSAIDs/Aspirin
Increased risk of gastrointestinal bleeding.
Warfarin and other anticoagulants
Altered anticoagulant effects; monitor INR.
Other serotonergic drugs (e.g., tramadol, St. John's Wort)
Increased risk of serotonin syndrome.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include dizziness, tremor, somnolence, nausea, vomiting, tachycardia, and convulsions. Management involves supportive measures, airway maintenance, and activated charcoal. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Escitalopram is excreted in breast milk; advise caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to escitalopram or citalopram.
- Concomitant use of Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing an MAOI, or starting an MAOI within 14 days of discontinuing escitalopram.
- Congenital long QT syndrome or concomitant use with other QT-prolonging medicinal products.
Drug Interactions
MAOIs
Risk of serious, sometimes fatal, reactions including serotonin syndrome.
Triptans
Increased risk of serotonin syndrome.
NSAIDs/Aspirin
Increased risk of gastrointestinal bleeding.
Warfarin and other anticoagulants
Altered anticoagulant effects; monitor INR.
Other serotonergic drugs (e.g., tramadol, St. John's Wort)
Increased risk of serotonin syndrome.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include dizziness, tremor, somnolence, nausea, vomiting, tachycardia, and convulsions. Management involves supportive measures, airway maintenance, and activated charcoal. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Escitalopram is excreted in breast milk; advise caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 24-36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of escitalopram in the treatment of MDD, GAD, PD, SAD, and OCD.
Lab Monitoring
- Monitor electrolyte levels (especially sodium) in patients at risk of hyponatremia.
- Liver function tests (LFTs) periodically, especially in patients with hepatic impairment.
- ECG monitoring in patients with cardiac risk factors or concomitant QT-prolonging drugs.
Doctor Notes
- Always assess for suicidal ideation, especially at the initiation of therapy or after dose adjustments.
- Counsel patients on the importance of adherence and not discontinuing treatment abruptly.
- Be aware of potential drug interactions, especially with MAOIs and other serotonergic agents.
Patient Guidelines
- Take the medicine consistently as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor, as it can lead to withdrawal symptoms.
- Report any new or worsening symptoms, especially mood changes or suicidal thoughts, to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness, somnolence, or blurred vision. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Regular exercise and a balanced diet can support mental well-being.
- Avoid alcohol and recreational drugs, as they can worsen your condition or interact with the medication.
- Practice stress management techniques like meditation or mindfulness.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Lexa Brand
Other medicines available under the same brand name
