Tablets should be swallowed whole with water. Can be taken with or without food. To be used for short-term treatment only.

Bromazepam enhances the effect of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, at the GABAA receptor in the central nervous system. This leads to increased chloride ion influx, hyperpolarization of the neuron, and decreased neuronal excitability, resulting in anxiolytic, sedative, and muscle relaxant effects.

• •Hypersensitivity to bromazepam or other benzodiazepines
• •Myasthenia gravis
• •Severe respiratory insufficiency
• •Severe hepatic insufficiency
• •Sleep apnea syndrome

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Symptoms include drowsiness, confusion, ataxia, diminished reflexes, hypotension, respiratory depression, and coma. Management involves supportive care, maintaining airway, monitoring vital signs, and if severe, administration of flumazenil (a benzodiazepine receptor antagonist).

Pregnancy Category D. Not recommended during pregnancy, especially in the first trimester, due to potential risks of congenital malformations. Avoid during lactation as it passes into breast milk and may cause sedation in the infant.