Medicine Information

Lexopam

Name: Lexopam
Brand: Lexopam
Rating: 4.5 (117 reviews)

Tablet3 mgAnxiolytic, Sedative-HypnoticATC: N05BA08

Generic Name

Bromazepam

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
lexopam 3 mg tablet	৳ 4.50	৳ 45.00

Description

Overview of the medicine

Lexopam (Bromazepam) is a benzodiazepine derivative with anxiolytic, sedative, muscle relaxant, and anticonvulsant properties. It is primarily used for the short-term treatment of anxiety, tension, and related somatic or psychiatric conditions, as well as insomnia.

Uses & Indications

Short-term treatment of anxiety, tension, and apprehension

Anxiety associated with somatic complaints

Insomnia caused by anxiety or tension

Dosage

Adults

Typical daily dose is 3-18 mg, divided into 2-3 doses. In severe cases, up to 30 mg daily. Treatment should be as short as possible.

Elderly

Initially, a lower dose of 1.5 mg once or twice daily. Gradually increase if needed and tolerated.

Renal_impairment

Use with caution and consider dose reduction; monitor for adverse effects.

How to Take

Tablets should be swallowed whole with water. Can be taken with or without food. To be used for short-term treatment only.

Mechanism of Action

Bromazepam enhances the effect of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, at the GABAA receptor in the central nervous system. This leads to increased chloride ion influx, hyperpolarization of the neuron, and decreased neuronal excitability, resulting in anxiolytic, sedative, and muscle relaxant effects.

Pharmacokinetics

Onset

Approximately 30-60 minutes.

Excretion

Mainly excreted in the urine as metabolites.

Half life

Approximately 10-20 hours.

Absorption

Rapidly and almost completely absorbed from the gastrointestinal tract; peak plasma concentrations achieved within 1-2 hours.

Metabolism

Extensively metabolized in the liver, primarily by CYP3A4, into inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to bromazepam or other benzodiazepines
Myasthenia gravis
Severe respiratory insufficiency
Severe hepatic insufficiency
Sleep apnea syndrome

Drug Interactions

CYP3A4 Inducers (e.g., rifampicin, carbamazepine)

May decrease bromazepam plasma concentrations and reduce its effects.

CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin)

May increase bromazepam plasma concentrations and enhance its effects.

CNS Depressants (e.g., alcohol, opioids, antidepressants)

Increased sedative effect, respiratory depression, hypotension.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms include drowsiness, confusion, ataxia, diminished reflexes, hypotension, respiratory depression, and coma. Management involves supportive care, maintaining airway, monitoring vital signs, and if severe, administration of flumazenil (a benzodiazepine receptor antagonist).

Pregnancy & Lactation

Pregnancy Category D. Not recommended during pregnancy, especially in the first trimester, due to potential risks of congenital malformations. Avoid during lactation as it passes into breast milk and may cause sedation in the infant.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

3 mg x 10 tablets3 mg x 30 tablets

Shelf Life

Typically 24-36 months from manufacturing date.

Availability

Pharmacies nationwide

Approval Status

Approved (DGDA)

Patent Status

Expired

Clinical Trials

Bromazepam has been extensively studied in clinical trials demonstrating its efficacy in anxiety disorders and insomnia, with a well-established safety profile under short-term use.

Lab Monitoring

Routine liver function tests may be considered in prolonged therapy or in patients with hepatic impairment. Renal function should be monitored in patients with renal impairment.

Doctor Notes

Prescribe for the shortest effective duration to minimize dependence risk.
Counsel patients on risks of withdrawal and importance of gradual tapering.
Assess for history of substance abuse before prescribing.

Patient Guidelines

Do not stop taking this medicine suddenly, especially after prolonged use, as it may cause withdrawal symptoms.
Avoid alcohol and other CNS depressants while taking Lexopam.
Inform your doctor about all other medications you are taking.
Use for the shortest duration possible, as advised by your doctor.

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose to catch up.

Driving Precautions

This medicine can cause drowsiness, dizziness, and impaired concentration. Avoid driving or operating heavy machinery until you know how it affects you.

Lifestyle Advice

Practice relaxation techniques, maintain a regular sleep schedule, and engage in regular physical activity to help manage anxiety.
Limit caffeine and nicotine intake.