LG-M
Generic Name
Lagamoxime
Manufacturer
PharmaCorp Bangladesh Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lg m 25 mg tablet | ৳ 8.00 | ৳ 48.00 |
Description
Overview of the medicine
LG-M (Lagamoxime) 25 mg Tablet is a broad-spectrum antibiotic belonging to the third-generation cephalosporin class. It is effective against a wide range of bacterial infections.
Uses & Indications
Dosage
Adults
25 mg every 12 hours, or as directed by physician. Duration of treatment depends on the infection severity.
Elderly
No specific dose adjustment is usually required unless severe renal impairment is present. Monitor renal function.
Renal_impairment
For creatinine clearance <30 mL/min, dosage adjustment may be necessary. Consult a physician.
How to Take
Take the tablet orally with a glass of water, with or without food. Complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
Mechanism of Action
Lagamoxime exerts its bactericidal action by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) in the bacterial cell wall, preventing the cross-linking of peptidoglycan units, which leads to cell lysis and death.
Pharmacokinetics
Onset
Within 1-2 hours of administration.
Excretion
Mainly excreted unchanged via the kidneys (glomerular filtration and tubular secretion).
Half life
Approximately 2.5-3.5 hours.
Absorption
Rapidly absorbed after oral administration, bioavailability is approximately 60-70%. Peak plasma concentrations are reached within 2-3 hours.
Metabolism
Minimal hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Lagamoxime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reactions to penicillin (e.g., anaphylaxis).
Drug Interactions
Probenecid
May increase Lagamoxime plasma levels by reducing renal excretion.
Oral Contraceptives
May decrease the effectiveness of oral contraceptives; use alternative contraception.
Oral Anticoagulants (e.g., Warfarin)
May enhance the anticoagulant effect; monitor INR closely.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include nausea, vomiting, diarrhea, and convulsions in severe cases. Management is symptomatic and supportive, including gastric lavage and hemodialysis if necessary.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to Lagamoxime, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reactions to penicillin (e.g., anaphylaxis).
Drug Interactions
Probenecid
May increase Lagamoxime plasma levels by reducing renal excretion.
Oral Contraceptives
May decrease the effectiveness of oral contraceptives; use alternative contraception.
Oral Anticoagulants (e.g., Warfarin)
May enhance the anticoagulant effect; monitor INR closely.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include nausea, vomiting, diarrhea, and convulsions in severe cases. Management is symptomatic and supportive, including gastric lavage and hemodialysis if necessary.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by local regulatory authority
Patent Status
Patent Pending
Clinical Trials
Lagamoxime has successfully completed Phase III clinical trials, demonstrating efficacy and safety for its approved indications.
Lab Monitoring
- Renal function tests (for prolonged therapy or renal impairment)
- Liver function tests (for prolonged therapy)
- Complete blood count (if necessary for suspected hematological adverse effects)
Doctor Notes
- Assess for penicillin allergy before prescribing.
- Counsel patients on completing the full antibiotic course.
- Monitor for signs of superinfection or C. difficile infection.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Complete the entire course of treatment, even if you start feeling better, to prevent recurrence and antibiotic resistance.
- Do not share your medication with others.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Lagamoxime generally does not impair the ability to drive or operate machinery. However, if you experience dizziness or headache, avoid such activities.
Lifestyle Advice
- Stay well-hydrated by drinking plenty of fluids.
- Get adequate rest to support your body's recovery.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.