Lijenta
Generic Name
Linagliptin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lijenta 5 mg tablet | ৳ 22.00 | ৳ 330.00 |
Description
Overview of the medicine
Lijenta 5 mg Tablet contains Linagliptin, an oral medicine used to help control blood sugar levels in adults with type 2 diabetes mellitus. It is used as an adjunct to diet and exercise.
Uses & Indications
Dosage
Adults
The recommended dose is 5 mg orally once daily, with or without food.
Elderly
No dosage adjustment required based on age.
Renal_impairment
No dosage adjustment required in patients with renal impairment, including those on dialysis.
How to Take
Administer orally once daily, at any time of day, with or without food.
Mechanism of Action
Linagliptin inhibits the enzyme dipeptidyl peptidase-4 (DPP-4), which normally degrades incretin hormones (GLP-1 and GIP). By inhibiting DPP-4, linagliptin increases the levels of active incretin hormones, leading to increased insulin synthesis and release from pancreatic beta cells and decreased glucagon secretion from pancreatic alpha cells. This results in glucose-dependent lowering of blood sugar.
Pharmacokinetics
Onset
Glycemic control observed within a few days of initiation.
Excretion
Primarily excreted unchanged via bile/faeces (about 80%), with a smaller portion (about 5%) excreted via urine.
Half life
Apparent terminal half-life is >100 hours, but effective half-life for DPP-4 inhibition is about 12 hours.
Absorption
Rapidly absorbed. Peak plasma concentration (Cmax) reached within 1.5 hours. Absolute bioavailability is approximately 30%.
Metabolism
Limited metabolism; primarily CYP3A4-mediated minor metabolism (approximately 10%).
Side Effects
Contraindications
- Hypersensitivity to linagliptin or any component of the formulation.
- Patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis.
Drug Interactions
Rifampin
Decreases linagliptin exposure, potentially reducing efficacy. Avoid coadministration if possible.
Insulin/Sulfonylureas
May increase risk of hypoglycemia; a lower dose of insulin or sulfonylurea may be required.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, no specific antidote is known. Symptomatic and supportive treatment should be initiated as appropriate for the patient's clinical state.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. It is not known whether linagliptin is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
FDA approved
Patent Status
Patented for innovator, generics available
Clinical Trials
Extensive clinical trials have demonstrated linagliptin's efficacy and safety in improving glycemic control in type 2 diabetes, both as monotherapy and in combination with other antidiabetic agents. Large cardiovascular outcome trials (CARMELINA) have shown cardiovascular safety.
Lab Monitoring
- Regular monitoring of blood glucose levels and HbA1c is essential to assess glycemic control.
- Renal function monitoring is not specifically required for linagliptin dosage adjustment but is important for overall diabetes management.
Doctor Notes
- Linagliptin offers the advantage of no dose adjustment required for renal or hepatic impairment.
- Educate patients on hypoglycemia symptoms, especially when combined with insulin/sulfonylureas, and management strategies.
- Monitor for signs and symptoms of pancreatitis and discontinue if suspected.
Patient Guidelines
- Take the tablet once daily at the same time each day, with or without food.
- Do not stop taking this medicine without consulting your doctor, even if you feel better.
- Follow your doctor's advice on diet and exercise to optimize blood sugar control.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Linagliptin itself does not directly affect the ability to drive or operate machinery. However, if used in combination with sulfonylureas or insulin, the risk of hypoglycemia may affect driving ability.
Lifestyle Advice
- Maintain a healthy, balanced diet and engage in regular physical activity.
- Monitor blood sugar levels regularly as advised by your healthcare provider and report any unusual symptoms.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.