Limpa
Generic Name
Teneligliptin
Manufacturer
Hypothetical Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| limpa 10 mg tablet | ৳ 35.00 | ৳ 350.00 |
Description
Overview of the medicine
Teneligliptin is an oral antidiabetic drug used to improve glycemic control in adults with type 2 diabetes mellitus.
Uses & Indications
Dosage
Adults
The recommended dose is 10 mg orally once daily. The dose may be increased to 20 mg once daily based on the patient's condition and glycemic control.
Elderly
No dose adjustment is required based on age alone.
Renal_impairment
No dose adjustment is required for mild to moderate renal impairment. For severe renal impairment or end-stage renal disease, dose adjustment may be considered by a physician.
How to Take
Take orally, once daily, with or without food. Swallow the tablet whole with water.
Mechanism of Action
Teneligliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by increasing the levels of incretin hormones (GLP-1 and GIP), which in turn enhances glucose-dependent insulin secretion from pancreatic beta cells and decreases glucagon secretion from pancreatic alpha cells, leading to improved blood glucose control.
Pharmacokinetics
Onset
Within hours of administration, with sustained effect over 24 hours.
Excretion
Excreted renally and hepatically. Approximately 30-60% excreted unchanged in urine.
Half life
Approximately 24 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentration reached within 1-2 hours.
Metabolism
Primarily metabolized by CYP3A4 and flavin-containing monooxygenase (FMO1 and FMO3).
Side Effects
Contraindications
- Hypersensitivity to teneligliptin or any component of the formulation.
- Type 1 diabetes mellitus.
- Diabetic ketoacidosis.
Drug Interactions
Sulfonylureas or Insulin
Increased risk of hypoglycemia when used in combination; dose reduction of sulfonylurea/insulin may be required.
Other Antidiabetic Agents
Additive effects on glycemic control.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
In case of an overdose, symptomatic and supportive treatment should be initiated. Teneligliptin is unlikely to be removed by hemodialysis.
Pregnancy & Lactation
Limited data on use in pregnancy. Should be used only if the potential benefit justifies the potential risk to the fetus. Avoid use during lactation as it is unknown if teneligliptin is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved
Patent Status
Off-patent in many countries; specific formulation patents may exist.
Clinical Trials
Teneligliptin has undergone extensive clinical trials demonstrating its efficacy and safety in improving glycemic control in patients with type 2 diabetes mellitus, both as monotherapy and in combination with other antidiabetic agents.
Lab Monitoring
- HbA1c levels (regularly)
- Fasting plasma glucose
- Postprandial glucose
- Renal function (creatinine, eGFR) periodically
Doctor Notes
- Emphasize lifestyle modifications (diet, exercise) as foundational therapy.
- Counsel patients on the symptoms of hypoglycemia, especially when used with sulfonylureas or insulin, and how to manage them.
- Monitor patients for signs and symptoms of pancreatitis and discontinue if suspected.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking Limpa 10 mg tablet without consulting your doctor.
- Monitor your blood glucose levels regularly as advised.
- Report any unusual symptoms or side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Limpa 10 mg tablet may cause dizziness or hypoglycemia, particularly if used with sulfonylureas or insulin. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a balanced diet and engage in regular physical activity.
- Avoid excessive alcohol consumption.
- Regularly consult your doctor and follow all lifestyle recommendations for diabetes management.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.