Linadus-M XR
Generic Name
Linagliptin 5 mg and Metformin Hydrochloride Extended-Release Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| linadus m xr 5 mg tablet | ৳ 24.00 | ৳ 144.00 |
Description
Overview of the medicine
Linadus-M XR is an oral antidiabetic medication combining Linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and Metformin Hydrochloride, a biguanide. It is used to improve glycemic control in adults with type 2 diabetes mellitus.
Uses & Indications
Dosage
Adults
Recommended starting dose is 5 mg Linagliptin/500 mg Metformin XR once daily. Titrate gradually to a maximum of 5 mg Linagliptin/2000 mg Metformin XR once daily with the evening meal. Do not exceed 5 mg Linagliptin and 2000 mg Metformin XR daily.
Elderly
Dosage should be individualized based on renal function. Initiate with a lower dose if renal function is compromised.
Renal_impairment
Metformin is contraindicated in severe renal impairment (eGFR <30 mL/min/1.73 m²). Dosing adjustments may be needed for moderate impairment (eGFR 30-45 mL/min/1.73 m²).
How to Take
Take orally once daily with the evening meal. Swallow the tablet whole; do not crush, cut, or chew.
Mechanism of Action
Linagliptin inhibits DPP-4, an enzyme that degrades incretin hormones (GLP-1 and GIP). By inhibiting DPP-4, Linagliptin increases and prolongs active incretin levels, which enhances glucose-dependent insulin secretion and suppresses glucagon secretion. Metformin reduces hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
Pharmacokinetics
Onset
Glycemic effects typically observed within a few days to weeks.
Excretion
Linagliptin: Primarily excreted unchanged in feces (80%), minor renal excretion. Metformin: Primarily excreted unchanged in urine.
Half life
Linagliptin: Effective half-life ~12 hours. Metformin: Plasma elimination half-life ~7 hours.
Absorption
Linagliptin: Rapidly absorbed, peak plasma concentration (Cmax) reached in 1.5 hours. Metformin: Slowly and incompletely absorbed, Tmax 4-8 hours for XR formulation.
Metabolism
Linagliptin: Limited metabolism, primarily by cleavage of piperidine ring. Metformin: Not metabolized in humans.
Side Effects
Contraindications
- •Severe renal impairment (eGFR <30 mL/min/1.73 m²)
- •Metabolic acidosis, including diabetic ketoacidosis
- •Known hypersensitivity to Linagliptin or Metformin
- •Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma
Drug Interactions
Alcohol
Increases the risk of lactic acidosis with Metformin.
Rifampin
Reduced efficacy of Linagliptin.
Carbonic Anhydrase Inhibitors (e.g., topiramate, acetazolamide)
May increase risk of lactic acidosis with Metformin.
Cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, ranitidine, triamterene, trimethoprim, vancomycin)
May increase Metformin accumulation by competing for renal tubular transport systems.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Overdose of Metformin may lead to lactic acidosis, which requires emergency medical attention. Linagliptin overdose may lead to mild gastrointestinal symptoms. Treatment is symptomatic and supportive; hemodialysis can be effective for Metformin removal.
Pregnancy & Lactation
Use during pregnancy is not recommended unless clearly necessary. Limited data on human lactation; consider alternatives or discontinue breastfeeding if required.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved (DGDA)
Patent Status
Patent protected (Linagliptin component)
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Global Brand Names
International brand names for this medicine
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