Lipidof
Generic Name
Fenofibrate
Manufacturer
Hypothetical Pharma Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lipidof 200 mg capsule | ৳ 7.04 | ৳ 70.40 |
Description
Overview of the medicine
Lipidof 200 mg Capsule contains Fenofibrate, a lipid-regulating agent used to lower high levels of cholesterol and triglycerides in the blood. It helps prevent and treat conditions caused by high lipid levels, such as cardiovascular disease.
Uses & Indications
Dosage
Adults
The usual dose is one 200 mg capsule once daily, taken with a meal. Dosage should be individualized based on lipid levels and patient response.
Elderly
No specific dose adjustment is required in elderly patients with normal renal function. Initiate with the lowest effective dose.
Renal_impairment
Contraindicated in severe renal impairment (CrCl < 30 mL/min). In moderate renal impairment (CrCl 30-59 mL/min), dosage should be reduced (e.g., 54 mg or 48 mg daily depending on the formulation) and monitored closely. Not recommended for 200 mg formulation.
How to Take
Take the capsule orally, once daily, with a main meal. Swallow whole with water; do not chew or crush.
Mechanism of Action
Fenofibrate is a peroxisome proliferator-activated receptor alpha (PPARα) agonist. It activates PPARα, which in turn upregulates the expression of genes involved in lipoprotein metabolism, leading to increased lipolysis and elimination of triglyceride-rich particles from plasma, and an increase in HDL-C.
Pharmacokinetics
Onset
Lipid-lowering effects typically observed within 2-5 days, maximal effect within 4-8 weeks.
Excretion
Primarily excreted in the urine as fenofibric acid and its glucuronide conjugate. A small amount is excreted in the feces.
Half life
The plasma half-life of fenofibric acid (active metabolite) is approximately 20-23 hours.
Absorption
Well absorbed from the gastrointestinal tract, especially when taken with food. Bioavailability is enhanced with food.
Metabolism
Fenofibrate is rapidly hydrolyzed by esterases to its active metabolite, fenofibric acid, which then undergoes glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to fenofibrate or to any of the excipients.
- Severe renal impairment (CrCl < 30 mL/min).
- Severe hepatic impairment, including primary biliary cirrhosis and unexplained persistent liver function abnormality.
- Pre-existing gallbladder disease.
- Known photoallergy or phototoxic reaction during treatment with fibrates or ketoprofen.
Drug Interactions
Cyclosporine
May cause reversible impairment of renal function. Monitor renal function closely.
Oral Anticoagulants (e.g., Warfarin)
Potentiates the anticoagulant effect, increasing the risk of bleeding. Close monitoring of INR and anticoagulant dose adjustment is required.
Statins (HMG-CoA Reductase Inhibitors)
Increased risk of myopathy and rhabdomyolysis. Use with caution, especially in patients with predisposing factors for myopathy.
Bile Acid Resins (e.g., Cholestyramine)
May reduce the absorption of fenofibrate. Administer fenofibrate at least 1 hour before or 4-6 hours after bile acid resins.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
There is no specific antidote for fenofibrate overdose. In case of overdose, provide symptomatic treatment and supportive measures. Gastric lavage may be indicated. Hemodialysis is not considered effective.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether fenofibrate is excreted in human milk, so caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved (DGDA, FDA equivalent in various countries)
Patent Status
Generic available
Clinical Trials
Fenofibrate has been extensively studied in various clinical trials, demonstrating its efficacy in reducing hypertriglyceridemia and improving lipid profiles in patients with dyslipidemia. Key trials include the FIELD study and ACCORD Lipid study which evaluated cardiovascular outcomes.
Lab Monitoring
- Liver function tests (ALT, AST) should be monitored periodically, especially during the first 12 months of treatment.
- Renal function tests (serum creatinine, eGFR) should be monitored regularly, particularly in elderly patients or those with kidney impairment.
- Lipid panel (total cholesterol, LDL-C, HDL-C, triglycerides) should be checked regularly to assess treatment efficacy.
Doctor Notes
- Emphasize the importance of concomitant diet and lifestyle modifications.
- Monitor LFTs and renal function prior to and during therapy, especially during the first year.
- Counsel patients on muscle symptoms and advise prompt reporting.
- Caution with co-administration of statins and warfarin, requiring dose adjustments and close monitoring.
Patient Guidelines
- Take Lipidof 200 mg Capsule exactly as prescribed by your doctor.
- Always take this medicine with a main meal to ensure proper absorption.
- Do not stop taking the medicine without consulting your doctor, even if you feel better.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember with your next meal. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Lipidof 200 mg Capsule is not known to impair the ability to drive or operate machinery. However, if you experience side effects like dizziness or blurred vision, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a heart-healthy diet low in saturated and trans fats, cholesterol, and refined sugars.
- Incorporate regular physical activity into your routine (e.g., moderate-intensity exercise for at least 30 minutes most days of the week).
- Achieve and maintain a healthy weight.
- Limit alcohol consumption and avoid smoking.
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