Lipidof
Generic Name
Fenofibrate
Manufacturer
Hypothetical Pharma Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lipidof 200 mg capsule | ৳ 7.04 | ৳ 70.40 |
Description
Overview of the medicine
Lipidof 200 mg Capsule contains Fenofibrate, a lipid-regulating agent used to lower high levels of cholesterol and triglycerides in the blood. It helps prevent and treat conditions caused by high lipid levels, such as cardiovascular disease.
Uses & Indications
Dosage
Adults
The usual dose is one 200 mg capsule once daily, taken with a meal. Dosage should be individualized based on lipid levels and patient response.
Elderly
No specific dose adjustment is required in elderly patients with normal renal function. Initiate with the lowest effective dose.
Renal_impairment
Contraindicated in severe renal impairment (CrCl < 30 mL/min). In moderate renal impairment (CrCl 30-59 mL/min), dosage should be reduced (e.g., 54 mg or 48 mg daily depending on the formulation) and monitored closely. Not recommended for 200 mg formulation.
How to Take
Take the capsule orally, once daily, with a main meal. Swallow whole with water; do not chew or crush.
Mechanism of Action
Fenofibrate is a peroxisome proliferator-activated receptor alpha (PPARα) agonist. It activates PPARα, which in turn upregulates the expression of genes involved in lipoprotein metabolism, leading to increased lipolysis and elimination of triglyceride-rich particles from plasma, and an increase in HDL-C.
Pharmacokinetics
Onset
Lipid-lowering effects typically observed within 2-5 days, maximal effect within 4-8 weeks.
Excretion
Primarily excreted in the urine as fenofibric acid and its glucuronide conjugate. A small amount is excreted in the feces.
Half life
The plasma half-life of fenofibric acid (active metabolite) is approximately 20-23 hours.
Absorption
Well absorbed from the gastrointestinal tract, especially when taken with food. Bioavailability is enhanced with food.
Metabolism
Fenofibrate is rapidly hydrolyzed by esterases to its active metabolite, fenofibric acid, which then undergoes glucuronidation.
Side Effects
Contraindications
- •Hypersensitivity to fenofibrate or to any of the excipients.
- •Severe renal impairment (CrCl < 30 mL/min).
- •Severe hepatic impairment, including primary biliary cirrhosis and unexplained persistent liver function abnormality.
- •Pre-existing gallbladder disease.
- •Known photoallergy or phototoxic reaction during treatment with fibrates or ketoprofen.
Drug Interactions
Cyclosporine
May cause reversible impairment of renal function. Monitor renal function closely.
Oral Anticoagulants (e.g., Warfarin)
Potentiates the anticoagulant effect, increasing the risk of bleeding. Close monitoring of INR and anticoagulant dose adjustment is required.
Statins (HMG-CoA Reductase Inhibitors)
Increased risk of myopathy and rhabdomyolysis. Use with caution, especially in patients with predisposing factors for myopathy.
Bile Acid Resins (e.g., Cholestyramine)
May reduce the absorption of fenofibrate. Administer fenofibrate at least 1 hour before or 4-6 hours after bile acid resins.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
There is no specific antidote for fenofibrate overdose. In case of overdose, provide symptomatic treatment and supportive measures. Gastric lavage may be indicated. Hemodialysis is not considered effective.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether fenofibrate is excreted in human milk, so caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved (DGDA, FDA equivalent in various countries)
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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