Livacin
Generic Name
Levofloxacin 0.5% Ophthalmic Solution
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| livacin 05 eye drop | ৳ 90.27 | N/A |
Description
Overview of the medicine
Livacin 0.5% Eye Drop is a topical antibiotic containing Levofloxacin, used to treat bacterial infections of the eye such as bacterial conjunctivitis and corneal ulcers.
Uses & Indications
Dosage
Adults
For bacterial conjunctivitis: 1-2 drops into the affected eye(s) every 2 hours while awake for the first 2 days, then every 4 hours while awake for the next 5 days. For corneal ulcers: Initial 1-2 drops every 30 minutes for the first 6 hours, then 1-2 drops every hour for day 1. Days 2-3: 1-2 drops every 4 hours. Days 4-end of treatment: 1-2 drops 2-3 times daily.
Elderly
No dosage adjustment is typically required for elderly patients.
Renal_impairment
No dosage adjustment is necessary for topical ophthalmic use, even in patients with renal impairment, due to minimal systemic absorption.
How to Take
For ophthalmic use only. Tilt your head back, gently pull down your lower eyelid, and instill the prescribed number of drops into the conjunctival sac. Do not allow the dropper tip to touch your eye or any other surface to avoid contamination.
Mechanism of Action
Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Onset of action is relatively rapid, with bacterial inhibition occurring within minutes to hours of administration.
Excretion
If systemically absorbed, it is primarily excreted via the kidneys in urine.
Half life
Not well-defined for topical ocular use due to minimal systemic absorption. Systemic half-life of levofloxacin is approximately 6-8 hours.
Absorption
Minimal systemic absorption occurs after topical ocular administration. Peak plasma concentrations are very low, suggesting limited systemic exposure.
Metabolism
Levofloxacin undergoes minimal metabolism; it is primarily excreted as the unchanged drug.
Side Effects
Contraindications
- Hypersensitivity to levofloxacin, other quinolones, or any component of the formulation.
- Viral or fungal eye infections.
Drug Interactions
Other topical ophthalmic solutions
Avoid concurrent use with other topical ocular medications without consulting a doctor. If multiple eye medications are used, administer them at least 5-10 minutes apart to prevent dilution and ensure proper absorption.
Storage
Store at room temperature (15-30°C). Protect from light and moisture. Do not freeze.
Overdose
Overdose is unlikely with topical ocular administration. If accidentally swallowed, contact a poison control center or seek medical attention.
Pregnancy & Lactation
Use during pregnancy or lactation only if the potential benefit justifies the potential risk to the fetus or infant. Consult a healthcare professional before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 years unopened. Discard 28 days after opening.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Clinical trials have demonstrated the efficacy and safety of levofloxacin ophthalmic solution in treating various bacterial eye infections, showing significant bacterial eradication rates and clinical cure.
Lab Monitoring
- No specific laboratory monitoring is typically required for topical ophthalmic levofloxacin.
Doctor Notes
- Educate patients on proper eye drop instillation technique to maximize efficacy and minimize contamination.
- Emphasize the importance of completing the full course of therapy, even if symptoms improve, to prevent resistance and recurrence.
Patient Guidelines
- Do not wear contact lenses during the entire course of treatment for eye infections.
- Wash your hands thoroughly before and after applying the eye drops.
- Complete the full prescribed course of treatment, even if your symptoms improve.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
This medication may cause temporary blurring of vision immediately after application. Avoid driving or operating machinery until your vision has cleared.
Lifestyle Advice
- Avoid rubbing your eyes unnecessarily to prevent irritation and further contamination.
- Practice good eye hygiene to prevent reinfection.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.