Locopain-TR
Generic Name
Tramadol Hydrochloride Extended-Release
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| locopain tr 100 mg capsule | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Locopain-TR 100 mg Capsule contains Tramadol Hydrochloride, an opioid analgesic used for the management of moderate to severe chronic pain. The extended-release formulation allows for once-daily dosing.
Uses & Indications
Dosage
Adults
Initial: 100 mg once daily. May be titrated up to 300 mg once daily based on pain and tolerability. Do not exceed 300 mg/day.
Elderly
For patients > 75 years, adjust dosage cautiously. Maximum 300 mg/day.
Renal_impairment
Creatinine clearance < 30 mL/min, dosage adjustment may be required. Typically, 50-100 mg every 12 hours or avoid extended-release formulation.
How to Take
Swallow the capsule whole; do not crush, chew, or split. Can be taken with or without food.
Mechanism of Action
Tramadol acts as a central analgesic with a dual mechanism: it binds to μ-opioid receptors and inhibits the reuptake of norepinephrine and serotonin, enhancing descending pain inhibitory pathways.
Pharmacokinetics
Onset
Analgesia typically begins within 1 hour, sustained effect over 24 hours.
Excretion
Mainly through the kidneys (approximately 90%), with a small amount in feces.
Half life
Approximately 6-7 hours for tramadol and 7-9 hours for its active metabolite O-desmethyltramadol.
Absorption
Well absorbed orally, extended-release formulation provides sustained plasma concentrations.
Metabolism
Primarily in the liver via CYP2D6 to active metabolite O-desmethyltramadol, and other less active metabolites.
Side Effects
Contraindications
- Hypersensitivity to tramadol or opioids
- Acute intoxication with alcohol, hypnotics, analgesics, opioids, or psychotropic drugs
- Patients receiving MAO inhibitors or within 14 days of stopping them
- Severe respiratory depression
- Acute bronchial asthma in unmonitored settings or in absence of resuscitative equipment
Drug Interactions
Carbamazepine
Significantly decreases tramadol plasma levels.
MAO Inhibitors
Increased risk of serotonin syndrome and seizures.
Serotonergic Drugs (SSRIs, SNRIs, TCAs)
Increased risk of serotonin syndrome.
CNS Depressants (e.g., Benzodiazepines, Alcohol)
Increased risk of respiratory depression, sedation, coma, and death.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include respiratory depression, somnolence, coma, seizures, cardiac arrest, and death. Naloxone can reverse opioid effects; manage seizures with benzodiazepines.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and benefits outweigh risks. Tramadol is excreted in breast milk; advise against breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to tramadol or opioids
- Acute intoxication with alcohol, hypnotics, analgesics, opioids, or psychotropic drugs
- Patients receiving MAO inhibitors or within 14 days of stopping them
- Severe respiratory depression
- Acute bronchial asthma in unmonitored settings or in absence of resuscitative equipment
Drug Interactions
Carbamazepine
Significantly decreases tramadol plasma levels.
MAO Inhibitors
Increased risk of serotonin syndrome and seizures.
Serotonergic Drugs (SSRIs, SNRIs, TCAs)
Increased risk of serotonin syndrome.
CNS Depressants (e.g., Benzodiazepines, Alcohol)
Increased risk of respiratory depression, sedation, coma, and death.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include respiratory depression, somnolence, coma, seizures, cardiac arrest, and death. Naloxone can reverse opioid effects; manage seizures with benzodiazepines.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and benefits outweigh risks. Tramadol is excreted in breast milk; advise against breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacture date
Availability
Pharmacies, hospitals
Approval Status
Approved by health authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of tramadol extended-release formulations for chronic pain.
Lab Monitoring
- Monitor renal and hepatic function in patients with impairment.
- Monitor for signs of respiratory depression and CNS changes.
Doctor Notes
- Regularly assess patient's pain, functional status, and risk for opioid abuse.
- Consider tapering dose slowly to avoid withdrawal symptoms.
- Educate patients on safe storage and disposal of opioids.
Patient Guidelines
- Do not stop taking abruptly to avoid withdrawal symptoms.
- Avoid alcohol and other CNS depressants.
- Report any signs of unusual sleepiness, difficulty breathing, or allergic reactions immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or drowsiness, impairing ability to drive or operate machinery. Avoid such activities until you know how the medicine affects you.
Lifestyle Advice
- Engage in regular, light exercise if pain permits.
- Maintain a balanced diet to prevent constipation.
- Consider non-pharmacological pain management techniques.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.