Lofam
Generic Name
Lofepramine
Manufacturer
Incepta Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lofam 100 mg tablet | ৳ 3.00 | N/A |
Description
Overview of the medicine
Lofam 100 mg tablet contains Lofepramine, a tricyclic antidepressant used to treat depressive illnesses. It works by increasing the levels of certain natural substances in the brain that are necessary for mental balance.
Uses & Indications
Dosage
Adults
Initially 70 mg daily in divided doses, gradually increased up to 140-210 mg daily in divided doses. Maintenance dose is usually 70-140 mg daily.
Elderly
Lower initial doses are recommended, typically 35-70 mg daily, adjusted cautiously.
Renal_impairment
No specific dose adjustment guidelines; use with caution.
How to Take
Taken orally, usually once or twice daily, with or without food.
Mechanism of Action
Lofepramine acts by inhibiting the reuptake of norepinephrine and serotonin in the central nervous system, thereby increasing their concentrations in the synaptic cleft. This leads to an antidepressant effect.
Pharmacokinetics
Onset
Antidepressant effects typically begin within 2-4 weeks of continuous treatment.
Excretion
Excreted mainly via urine as metabolites, with some fecal excretion.
Half life
Parent drug: Approximately 5 hours; Active metabolite (desipramine): 12-24 hours.
Absorption
Well absorbed from the gastrointestinal tract.
Metabolism
Extensively metabolized in the liver, primarily to desipramine.
Side Effects
Contraindications
- •Hypersensitivity to Lofepramine or other TCAs
- •Recent myocardial infarction
- •Arrhythmias
- •Maniac phase of bipolar disorder
- •Severe liver disease
- •Concomitant use with MAOIs (within 14 days)
Drug Interactions
MAOIs
Concurrent use can lead to hyperpyretic crises, convulsions, and death. A gap of 14 days is required.
Anticholinergics
Potentiated anticholinergic effects (e.g., urinary retention, blurred vision).
CNS Depressants (alcohol, sedatives)
Increased CNS depression.
Adrenergic Neuron Blockers (e.g., guanethidine)
Reduced antihypertensive effect.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe drowsiness, confusion, rapid heartbeat, seizures, coma. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal.
Pregnancy & Lactation
Use in pregnancy only if potential benefit outweighs risk. Excreted in breast milk, so caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies
Approval Status
Approved
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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