Lopan
Generic Name
lopan-10-mg-tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lopan 10 mg tablet | ৳ 3.43 | ৳ 34.30 |
Description
Overview of the medicine
Lopan 10 mg Tablet is a benzodiazepine medication used to treat anxiety disorders, insomnia, and certain types of seizures. It works by affecting specific receptors in the brain to produce a calming effect. The 10 mg strength is typically used for severe conditions or specific medical scenarios.
Uses & Indications
Dosage
Adults
For anxiety: Typically 2-3 mg administered 2 or 3 times a day. For severe anxiety, up to 10 mg daily in divided doses may be considered. For insomnia: 2-4 mg at bedtime. Note: 10 mg is a high single dose for oral use and should be used with extreme caution for specific severe indications under medical supervision.
Elderly
Initially 1-2 mg daily in divided doses, increasing cautiously if needed. Lower doses are generally recommended due to increased sensitivity and potential for adverse effects.
Renal_impairment
No specific dose adjustment is generally required, but caution is advised, and lower doses may be considered.
How to Take
Take the tablet orally with or without food. Swallow whole with water. Do not chew or crush.
Mechanism of Action
Lorazepam, the active ingredient in Lopan, enhances the effect of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits brain activity. This results in sedative, hypnotic, anxiolytic, anticonvulsant, and muscle relaxant properties.
Pharmacokinetics
Onset
Onset of action for anxiety relief is typically within 20-30 minutes orally.
Excretion
Excreted mainly by the kidneys as glucuronide conjugates.
Half life
The elimination half-life is approximately 10-20 hours.
Absorption
Rapidly and completely absorbed after oral administration. Peak plasma concentrations are reached within 2 hours.
Metabolism
Primarily metabolized in the liver via glucuronidation to inactive compounds.
Side Effects
Contraindications
- •Hypersensitivity to lorazepam or other benzodiazepines.
- •Acute narrow-angle glaucoma.
- •Severe respiratory insufficiency.
- •Sleep apnea syndrome.
- •Myasthenia gravis.
Drug Interactions
Clofazine
May cause profound sedation, excessive salivation, and ataxia.
Valproate
Increases lorazepam plasma concentrations and enhances its effects.
Probenecid
Increases lorazepam plasma concentrations and extends its half-life.
Opioids, Alcohol, Other CNS Depressants
Increased risk of profound sedation, respiratory depression, coma, and death.
Storage
Store in a cool, dry place (below 30°C), protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, diminished reflexes, coma, and respiratory depression. Management is primarily supportive, with maintenance of vital signs and airway. Flumazenil may be used as an antidote but carries risks, especially in patients on chronic benzodiazepine therapy.
Pregnancy & Lactation
Category D in pregnancy (evidence of fetal risk). Not recommended, especially during the first trimester. Excreted into breast milk and may cause sedation in the infant; use is generally discouraged during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in