Lopez
Generic Name
Lorazepam
Manufacturer
Hypothetical Manufacturer
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lopez 5 mg tablet | ৳ 2.52 | ৳ 25.20 |
Description
Overview of the medicine
Lorazepam is a benzodiazepine used to treat anxiety disorders, insomnia, status epilepticus, and for preoperative sedation.
Uses & Indications
Dosage
Adults
Anxiety: 1-4 mg daily in divided doses. Insomnia: 2-4 mg at bedtime. For severe anxiety or specific indications, higher doses like 5 mg might be used under strict medical supervision.
Elderly
Initially 0.5-1 mg daily, adjusted as needed and tolerated due to increased sensitivity and risk of side effects.
Renal_impairment
No specific dosage adjustment required, but use with caution. Consider lower doses if severe impairment.
How to Take
Administer orally with or without food. For insomnia, take shortly before bedtime. Do not crush or chew sustained-release forms (if applicable).
Mechanism of Action
Lorazepam acts by enhancing the effect of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits activity in the brain, leading to anxiolytic, sedative, hypnotic, and anticonvulsant effects.
Pharmacokinetics
Onset
15-60 minutes (oral)
Excretion
Mainly renal excretion as glucuronides.
Half life
10-20 hours
Absorption
Rapid and complete absorption after oral administration.
Metabolism
Primarily hepatic glucuronidation to inactive metabolites.
Side Effects
Contraindications
- Known hypersensitivity to benzodiazepines or any component of the formulation
- Acute narrow-angle glaucoma
- Severe respiratory insufficiency
- Sleep apnea syndrome
- Myasthenia gravis
Drug Interactions
Clozapine
Increased risk of severe sedation, salivation, and uncoordination.
Valproate
Increases plasma concentration and reduces clearance of lorazepam, potentially increasing adverse effects.
Probenecid
Increases plasma concentration and prolongs the half-life of lorazepam.
Opioids, alcohol, and other CNS depressants
Increased risk of profound sedation, respiratory depression, coma, and death.
Storage
Store at room temperature (below 30°C), protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, confusion, lethargy, ataxia, dysarthria, hypotension, hypotonia, respiratory depression, and coma. Management involves supportive care, maintaining airway, and in severe cases, administration of flumazenil, a benzodiazepine receptor antagonist.
Pregnancy & Lactation
Pregnancy Category D: May cause fetal harm. Should not be used during pregnancy, especially during the first trimester. Excreted into breast milk; not recommended during lactation due to potential for sedation and feeding difficulties in infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date, check specific packaging for details.
Availability
Pharmacies
Approval Status
Approved (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Lorazepam has undergone extensive clinical trials demonstrating its efficacy and safety for various indications, leading to its widespread approval and use.
Lab Monitoring
- Periodic monitoring of liver function tests and complete blood count may be considered during prolonged therapy, especially in patients with pre-existing hepatic or renal impairment.
Doctor Notes
- Caution in elderly patients due to increased risk of falls and cognitive impairment.
- Monitor patients with respiratory compromise closely.
- Assess for a history of substance abuse prior to initiating therapy.
- Educate patients on the risks of concomitant opioid use and the importance of gradual tapering.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly, as this can cause withdrawal symptoms.
- Avoid alcohol and other CNS depressants.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Lopez (Lorazepam) can cause drowsiness, dizziness, and impaired coordination. Patients should be warned against engaging in hazardous occupations requiring complete mental alertness, such as operating machinery or driving a motor vehicle.
Lifestyle Advice
- Avoid driving or operating heavy machinery until you know how this medication affects you, as it can cause drowsiness and decreased alertness.
- Limit or avoid alcohol consumption while on this medication.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.