Lopresor
Generic Name
Metoprolol Tartrate
Manufacturer
AstraZeneca
Country
Multiple (e.g., Switzerland for original, various for generics)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lopresor 50 mg tablet | ৳ 1.30 | N/A |
Description
Overview of the medicine
Metoprolol is a cardioselective beta1-adrenergic blocker used to treat hypertension, angina pectoris, and heart failure.
Uses & Indications
Dosage
Adults
Varies by indication. For hypertension, typically 50-100 mg orally once daily or in divided doses.
Elderly
Initiate with lower doses and titrate carefully, as per individual response.
Renal_impairment
No dosage adjustment required in renal impairment, but caution in severe cases.
How to Take
Administer orally, usually with or immediately following meals.
Mechanism of Action
Selectively blocks beta1-adrenergic receptors, reducing heart rate, cardiac output, and blood pressure.
Pharmacokinetics
Onset
Oral: within 1 hour.
Excretion
Primarily renal (about 95% as metabolites, 5% as unchanged drug).
Half life
3-7 hours.
Absorption
Rapid and complete absorption after oral administration, but significant first-pass metabolism reduces bioavailability to about 50%.
Metabolism
Primarily hepatic, CYP2D6 is involved.
Side Effects
Contraindications
- Sinus bradycardia
- Greater than first-degree heart block
- Cardiogenic shock
- Overt cardiac failure
- Sick sinus syndrome (unless permanent pacemaker in place)
Drug Interactions
Clonidine
May cause rebound hypertension if clonidine is withdrawn abruptly while on metoprolol.
MAO Inhibitors
Increased risk of hypertension or hypotension.
Digitalis Glycosides
Increased risk of bradycardia.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia and AV block.
Storage
Store at room temperature, away from moisture and direct light. Keep out of reach of children.
Overdose
Symptoms include bradycardia, hypotension, bronchospasm, heart failure. Treatment is supportive, potentially including atropine, glucagon, IV fluids, vasopressors, bronchodilators.
Pregnancy & Lactation
Pregnancy category C; use only if potential benefit justifies potential risk to fetus. Metoprolol is excreted in breast milk; caution advised.
Side Effects
Contraindications
- Sinus bradycardia
- Greater than first-degree heart block
- Cardiogenic shock
- Overt cardiac failure
- Sick sinus syndrome (unless permanent pacemaker in place)
Drug Interactions
Clonidine
May cause rebound hypertension if clonidine is withdrawn abruptly while on metoprolol.
MAO Inhibitors
Increased risk of hypertension or hypotension.
Digitalis Glycosides
Increased risk of bradycardia.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia and AV block.
Storage
Store at room temperature, away from moisture and direct light. Keep out of reach of children.
Overdose
Symptoms include bradycardia, hypotension, bronchospasm, heart failure. Treatment is supportive, potentially including atropine, glucagon, IV fluids, vasopressors, bronchodilators.
Pregnancy & Lactation
Pregnancy category C; use only if potential benefit justifies potential risk to fetus. Metoprolol is excreted in breast milk; caution advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA)
Patent Status
Generic available, patent expired
WHO Essential Medicine
YesClinical Trials
Extensively studied in trials for hypertension, angina, MI, and heart failure, demonstrating efficacy and safety.
Lab Monitoring
- Blood pressure
- Heart rate
- ECG
- Renal function (in patients with severe impairment)
Doctor Notes
- Titrate dose slowly, especially in elderly or patients with heart failure.
- Monitor blood pressure and heart rate regularly.
- Educate patients on symptoms of bradycardia or hypotension.
Patient Guidelines
- Take exactly as prescribed.
- Do not stop taking the medicine abruptly.
- Report any unusual symptoms to your doctor.
- Avoid sudden changes in posture to prevent dizziness.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or fatigue, especially at the start of treatment. Patients should be cautioned about operating machinery or driving until effects are known.
Lifestyle Advice
- Maintain a healthy diet (low sodium, low fat).
- Engage in regular physical activity (as advised by doctor).
- Avoid smoking and excessive alcohol consumption.
- Manage stress effectively.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.