Lorades
Generic Name
Desloratadine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lorades 5 mg tablet | ৳ 2.51 | N/A |
Description
Overview of the medicine
Desloratadine is a non-drowsy antihistamine that provides relief from allergy symptoms such as sneezing, runny nose, itchy eyes, and hives. It is used to treat seasonal and perennial allergic rhinitis and chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
One 5 mg tablet once daily.
Elderly
No dosage adjustment typically required, but caution is advised in elderly patients with renal or hepatic impairment.
Renal_impairment
For severe renal impairment (creatinine clearance < 30 mL/min), a reduced frequency (e.g., 5 mg every other day) is recommended.
How to Take
Take orally, with or without food, at any time of day.
Mechanism of Action
Desloratadine is a long-acting, selective peripheral H1-receptor antagonist. It inhibits histamine release from mast cells and reduces inflammatory mediators, thereby alleviating allergic symptoms.
Pharmacokinetics
Onset
Antihistaminic effects generally begin within 1-2 hours.
Excretion
Excreted in urine (approx. 40%) and feces (approx. 13%) as glucuronide conjugates and unchanged drug.
Half life
The mean plasma elimination half-life is approximately 27 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in approximately 3 hours.
Metabolism
Extensively metabolized to 3-hydroxydesloratadine, an active metabolite, by CYP2D6 (though not a major pathway).
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
- Severe renal or hepatic impairment (use with caution).
Drug Interactions
Cimetidine
May increase plasma concentrations of desloratadine, though usually not clinically significant.
Fluoxetine
May increase plasma concentrations of desloratadine, though usually not clinically significant.
Azithromycin
May increase plasma concentrations of desloratadine, though usually not clinically significant.
Erythromycin
May increase plasma concentrations of desloratadine, though usually not clinically significant.
Ketoconazole
May increase plasma concentrations of desloratadine, though usually not clinically significant.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment is recommended. Hemodialysis does not remove desloratadine.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit outweighs the potential risk to the fetus. Desloratadine is excreted into breast milk, so caution is advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Expired/Generic available
Clinical Trials
Numerous clinical trials have demonstrated the efficacy and safety of desloratadine for allergic rhinitis and chronic idiopathic urticaria across various patient populations.
Lab Monitoring
- No specific routine lab monitoring required.
Doctor Notes
- Counsel patients that this is a non-drowsy antihistamine.
- Emphasize consistent daily dosing for optimal allergy relief.
- Advise patients to report any unusual or severe side effects, especially signs of hypersensitivity or liver issues.
- No dose adjustment is generally required in mild to moderate hepatic or renal impairment, but caution in severe cases.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor if your symptoms do not improve or worsen.
- Do not stop taking the medicine suddenly without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Although desloratadine is generally non-sedating, individuals should be aware of how they react to the medicine before driving or operating machinery.
Lifestyle Advice
- Avoid alcohol as it may increase drowsiness, although desloratadine is non-sedating.
- Stay hydrated to help manage dry mouth, a common side effect.
- Identify and avoid triggers for your allergies.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.