Loratin-Fast
Generic Name
Loratadine 10 mg
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| loratin fast 10 mg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Loratadine is a non-drowsy antihistamine used to relieve symptoms of seasonal allergies and chronic urticaria.
Uses & Indications
Dosage
Adults
10 mg (one tablet) once daily.
Elderly
No dosage adjustment is generally required for elderly patients with normal renal and hepatic function.
Renal_impairment
For patients with severe renal impairment (creatinine clearance < 30 mL/min) or hepatic impairment, a starting dose of 10 mg every other day is recommended.
How to Take
Take orally, with or without food. Do not chew or crush the tablet; swallow whole with water.
Mechanism of Action
Loratadine selectively blocks peripheral H1-histamine receptors, thereby inhibiting the effects of histamine and alleviating allergic symptoms without causing significant central nervous system effects.
Pharmacokinetics
Onset
Onset of action typically occurs within 1-3 hours.
Excretion
Approximately 40% excreted in urine and 42% in feces over 10 days, primarily as conjugated metabolites.
Half life
Loratadine: 8.4 hours (range 3-20 hours); Desloratadine (active metabolite): 27 hours (range 8.8-92 hours).
Absorption
Rapidly absorbed from the gastrointestinal tract. Food may delay absorption slightly.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (CYP3A4 and CYP2D6) to its primary active metabolite, descarboethoxyloratadine (desloratadine).
Side Effects
Contraindications
- Hypersensitivity to loratadine or any component of the formulation.
- Hypersensitivity to desloratadine.
Drug Interactions
Cimetidine
Co-administration with cimetidine may increase plasma concentrations of loratadine and desloratadine, usually without clinical significance.
Erythromycin
Co-administration with erythromycin may increase plasma concentrations of loratadine and desloratadine, usually without clinical significance.
Ketoconazole
Co-administration with ketoconazole may increase plasma concentrations of loratadine and its active metabolite desloratadine, but this is generally not clinically significant.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include somnolence, tachycardia, and headache. In case of overdose, symptomatic and supportive treatment should be initiated immediately. Gastric lavage may be considered. Loratadine is not effectively removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk, therefore not recommended during lactation. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to loratadine or any component of the formulation.
- Hypersensitivity to desloratadine.
Drug Interactions
Cimetidine
Co-administration with cimetidine may increase plasma concentrations of loratadine and desloratadine, usually without clinical significance.
Erythromycin
Co-administration with erythromycin may increase plasma concentrations of loratadine and desloratadine, usually without clinical significance.
Ketoconazole
Co-administration with ketoconazole may increase plasma concentrations of loratadine and its active metabolite desloratadine, but this is generally not clinically significant.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include somnolence, tachycardia, and headache. In case of overdose, symptomatic and supportive treatment should be initiated immediately. Gastric lavage may be considered. Loratadine is not effectively removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk, therefore not recommended during lactation. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from the date of manufacture, check package for exact expiry date.
Availability
Available in pharmacies and drugstores
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Loratadine has undergone extensive clinical trials demonstrating its efficacy and safety in treating allergic rhinitis and chronic urticaria. Post-marketing surveillance continues to monitor its safety profile.
Lab Monitoring
- Generally, no routine laboratory monitoring is required for loratadine therapy.
Doctor Notes
- Advise patients that loratadine is generally non-drowsy, but individual responses can vary.
- Consider dose adjustment in patients with severe hepatic or renal impairment.
- Monitor for symptom improvement and advise on allergen avoidance strategies.
Patient Guidelines
- Do not exceed the recommended dose.
- Inform your doctor or pharmacist if symptoms persist or worsen.
- If you experience any unusual symptoms, seek medical advice.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Loratadine is generally non-drowsy, but individual responses can vary. Caution is advised when driving or operating machinery until you know how the medication affects you.
Lifestyle Advice
- Avoid known allergens to reduce symptoms.
- Stay hydrated by drinking plenty of fluids.
- Maintain a healthy lifestyle to support overall well-being.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.