Alcanta
Generic Name
Lorbrexen
Manufacturer
PharmaGen Inc.
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lorbrexen 100 mg tablet | ৳ 1,660.00 | N/A |
Description
Overview of the medicine
Lorbrexen is an anaplastic lymphoma kinase (ALK) and ROS1 tyrosine kinase inhibitor indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in adult patients.
Uses & Indications
Dosage
Adults
100 mg orally once daily
Elderly
No specific dose adjustment required based on age, but monitor for adverse reactions.
Renal_impairment
No dose adjustment needed for mild to moderate renal impairment. Severe renal impairment data limited.
How to Take
Take orally once daily, with or without food. Swallow whole, do not crush or chew.
Mechanism of Action
Lorbrexen inhibits ALK and ROS1 kinase activity, including their mutant forms, which are common drivers of NSCLC. It blocks tumor cell proliferation and survival.
Pharmacokinetics
Onset
Unknown, clinical effects observed within weeks.
Excretion
Mainly excreted via feces (approximately 90%) and urine (approximately 5%).
Half life
Approximately 24 hours.
Absorption
Rapidly absorbed with peak plasma concentrations occurring within 4 hours. Absolute bioavailability is approximately 81%.
Metabolism
Primarily metabolized by CYP3A4 and UGT1A4.
Side Effects
Contraindications
- Hypersensitivity to Lorbrexen or any excipients
- Co-administration with strong CYP3A inducers
Drug Interactions
Strong CYP3A inducers (e.g., Rifampin, Phenytoin)
Avoid concurrent use due to decreased Lorbrexen plasma concentrations.
Strong CYP3A inhibitors (e.g., Ketoconazole, Ritonavir)
Monitor for increased Lorbrexen adverse reactions.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
No specific antidote. Manage symptoms supportively. Contact poison control center.
Pregnancy & Lactation
Not recommended during pregnancy due to potential fetal harm. Advise women of reproductive potential to use effective contraception. Avoid breastfeeding during treatment and for 7 days after the last dose.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Specialty pharmacies, hospitals
Approval Status
Approved by FDA (USA) and DGDA (Bangladesh)
Patent Status
Patented
Clinical Trials
Ongoing clinical trials investigating efficacy in other cancer types and earlier lines of therapy.
Lab Monitoring
- Lipids (cholesterol and triglycerides) before and during treatment
- Liver function tests (ALT, AST, bilirubin) before and during treatment
Doctor Notes
- Prioritize patient education on potential neurological and metabolic side effects.
- Regularly monitor lipid profiles, liver function, and blood pressure.
Patient Guidelines
- Take exactly as prescribed.
- Report any new or worsening side effects.
- Avoid grapefruit products.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is less than 12 hours before the next scheduled dose, skip the missed dose and take the next dose at the regular time. Do not take two doses at the same time.
Driving Precautions
May cause dizziness or cognitive effects; advise caution when driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet to manage lipid levels.
- Engage in regular, moderate exercise if tolerated.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.