Losapot Plus
Generic Name
Losartan Potassium + Hydrochlorothiazide
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| losapot plus 100 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Losapot Plus 100 mg tablet is a combination medicine used to treat high blood pressure (hypertension). It contains Losartan, an angiotensin II receptor blocker, and Hydrochlorothiazide, a thiazide diuretic, which work together to lower blood pressure effectively.
Uses & Indications
Dosage
Adults
Usually one tablet once daily. May be increased if necessary after consultation with a physician.
Elderly
No initial dosage adjustment required for most elderly patients, but monitoring is advised.
Renal_impairment
Use with caution; not recommended for patients with severe renal impairment (creatinine clearance <30 mL/min).
How to Take
To be taken orally, with or without food, usually once daily. It is advisable to take it at the same time each day, preferably in the morning.
Mechanism of Action
Losartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor. Hydrochlorothiazide increases the excretion of sodium and chloride in the urine by inhibiting sodium reabsorption in the distal convoluted tubule, leading to diuresis and a reduction in blood volume.
Pharmacokinetics
Onset
Losartan: 1 hour, peak effect 6 hours. Hydrochlorothiazide: 2 hours, peak effect 4-6 hours. Combined effect typically within 3-6 hours.
Excretion
Losartan and its active metabolite are primarily excreted in the urine (35%) and feces (60%). Hydrochlorothiazide is primarily excreted unchanged in the urine (95%).
Half life
Losartan: 2 hours (active metabolite 6-9 hours). Hydrochlorothiazide: 5.8-14.8 hours.
Absorption
Losartan is well absorbed orally, with an average bioavailability of about 33%. Hydrochlorothiazide is also well absorbed orally (60-80%).
Metabolism
Losartan undergoes extensive first-pass metabolism by cytochrome P450 enzymes (CYP2C9 and CYP3A4) to an active carboxylic acid metabolite (E-3174). Hydrochlorothiazide is not metabolized.
Side Effects
Contraindications
- Hypersensitivity to Losartan, Hydrochlorothiazide, or sulfonamide-derived drugs
- Anuria
- Severe renal impairment
- Severe hepatic impairment
- Pregnancy (second and third trimesters)
- Concomitant use with Aliskiren in patients with diabetes or renal impairment
Drug Interactions
NSAIDs
May reduce the antihypertensive effect and increase the risk of renal impairment.
Lithium
Increased serum lithium concentrations and toxicity.
ACE Inhibitors/Aliskiren
Increased risk of hypotension, hyperkalemia, and renal impairment.
Alcohol, barbiturates, or narcotics
Potentiation of orthostatic hypotension.
Potassium-sparing diuretics/Potassium supplements
Increased risk of hyperkalemia.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include hypotension, tachycardia, bradycardia, electrolyte disturbances, and dehydration. Treatment is symptomatic and supportive, including intravenous fluids and electrolyte correction.
Pregnancy & Lactation
Contraindicated in the second and third trimesters of pregnancy due to fetal toxicity. Not recommended during lactation as both components are excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to Losartan, Hydrochlorothiazide, or sulfonamide-derived drugs
- Anuria
- Severe renal impairment
- Severe hepatic impairment
- Pregnancy (second and third trimesters)
- Concomitant use with Aliskiren in patients with diabetes or renal impairment
Drug Interactions
NSAIDs
May reduce the antihypertensive effect and increase the risk of renal impairment.
Lithium
Increased serum lithium concentrations and toxicity.
ACE Inhibitors/Aliskiren
Increased risk of hypotension, hyperkalemia, and renal impairment.
Alcohol, barbiturates, or narcotics
Potentiation of orthostatic hypotension.
Potassium-sparing diuretics/Potassium supplements
Increased risk of hyperkalemia.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include hypotension, tachycardia, bradycardia, electrolyte disturbances, and dehydration. Treatment is symptomatic and supportive, including intravenous fluids and electrolyte correction.
Pregnancy & Lactation
Contraindicated in the second and third trimesters of pregnancy due to fetal toxicity. Not recommended during lactation as both components are excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Losartan/Hydrochlorothiazide combination in managing hypertension and reducing cardiovascular risks.
Lab Monitoring
- Serum electrolytes (potassium, sodium)
- Renal function (creatinine, BUN)
- Liver function tests
- Blood pressure monitoring
Doctor Notes
- Monitor serum electrolytes (especially potassium and sodium) and renal function regularly.
- Advise patients on lifestyle modifications to complement drug therapy.
- Caution against use in pregnant patients and those planning pregnancy.
Patient Guidelines
- Take as directed by your doctor, usually once daily.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
- Report any unusual symptoms, especially swelling of the face, lips, tongue, or throat.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or lightheadedness, especially when initiating treatment or increasing dose. Patients should be cautioned about driving or operating machinery until they know how they react to the medication.
Lifestyle Advice
- Follow a low-sodium diet.
- Maintain a healthy weight.
- Engage in regular physical activity.
- Avoid excessive alcohol consumption.
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