Losek
Generic Name
Omeprazole
Manufacturer
AstraZeneca
Country
Sweden/UK
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| losek 20 mg capsule | ৳ 4.00 | N/A |
| losek 40 mg capsule | ৳ 7.00 | N/A |
Description
Overview of the medicine
Losek (Omeprazole) is a proton pump inhibitor used to treat conditions caused by excess stomach acid, such as heartburn, acid reflux, and ulcers.
Uses & Indications
Dosage
Adults
For GERD: 20 mg once daily for 4-8 weeks. For Duodenal Ulcer: 20 mg once daily for 2-4 weeks. For Gastric Ulcer: 20 mg once daily for 4-8 weeks. For Zollinger-Ellison Syndrome: Initial 60 mg once daily, adjusted as needed.
Elderly
No dose adjustment generally required, but caution in impaired hepatic function.
Renal_impairment
No dose adjustment necessary.
How to Take
Usually taken once daily in the morning before a meal. Swallow capsules whole; do not chew or crush. For patients unable to swallow, capsules can be opened and granules mixed with a small amount of liquid or soft food.
Mechanism of Action
Omeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase (proton pump) in gastric parietal cells, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly excreted in urine (approx. 80%) and feces (approx. 20%) as metabolites.
Half life
0.5-1 hour (plasma elimination), but duration of acid suppression is longer due to irreversible binding.
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 30-40% at single doses, increasing to about 60% with repeated doses.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes, primarily CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or other benzimidazoles (e.g., esomeprazole, lansoprazole)
- Concomitant use with nelfinavir
Drug Interactions
Digoxin
Increased digoxin bioavailability.
Clopidogrel
Reduced antiplatelet effect (CYP2C19 inhibition).
Methotrexate
Increased methotrexate levels.
Nelfinavir, Atazanavir
Decreased plasma concentrations of these antivirals.
Warfarin, Diazepam, Phenytoin
Increased plasma levels due to inhibition of CYP2C19.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy category C. Use during pregnancy only if clearly needed. Excreted in breast milk, so caution is advised in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or other benzimidazoles (e.g., esomeprazole, lansoprazole)
- Concomitant use with nelfinavir
Drug Interactions
Digoxin
Increased digoxin bioavailability.
Clopidogrel
Reduced antiplatelet effect (CYP2C19 inhibition).
Methotrexate
Increased methotrexate levels.
Nelfinavir, Atazanavir
Decreased plasma concentrations of these antivirals.
Warfarin, Diazepam, Phenytoin
Increased plasma levels due to inhibition of CYP2C19.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy category C. Use during pregnancy only if clearly needed. Excreted in breast milk, so caution is advised in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by FDA and DGDA
Patent Status
Patent expired for generic omeprazole
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established omeprazole's efficacy and safety in various acid-related disorders.
Lab Monitoring
- Monitor INR in patients on warfarin
- Monitor magnesium levels with long-term use
- Monitor vitamin B12 levels with long-term use
Doctor Notes
- Consider bone density screening for patients on long-term PPI therapy.
- Educate patients on potential risks of long-term use.
- Review necessity of continued PPI therapy periodically.
Patient Guidelines
- Take exactly as prescribed.
- Do not stop taking without consulting your doctor.
- Inform your doctor about all other medications you are taking.
- Report any severe or persistent side effects.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid spicy and fatty foods.
- Limit alcohol and caffeine intake.
- Avoid smoking.
- Eat smaller, more frequent meals.
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