Lotepred-Plus
Generic Name
Loteprednol Etabonate 0.5% + Gatifloxacin 0.3% Ophthalmic Suspension
Manufacturer
Reputable Local/International Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lotepred plus 05 03 suspension | ৳ 200.00 | N/A |
Description
Overview of the medicine
Lotepred-Plus 0.5/0.3 Suspension is an ophthalmic combination medication containing Loteprednol Etabonate (a corticosteroid) and Gatifloxacin (a fluoroquinolone antibiotic). It is used to treat inflammatory ocular conditions where there is a risk of bacterial infection or an existing bacterial infection.
Uses & Indications
Dosage
Adults
Instill 1-2 drops into the conjunctival sac of the affected eye(s) 2-4 times daily, or as directed by a physician. The dosage may be tapered down gradually based on clinical response.
Elderly
No specific dosage adjustment is required for elderly patients.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment due to minimal systemic absorption.
How to Take
For topical ophthalmic use only. Shake the bottle well before each use. Tilt your head back, pull down the lower eyelid to form a pocket, and instill the prescribed number of drops. Do not touch the dropper tip to your eye or any other surface to avoid contamination.
Mechanism of Action
Loteprednol Etabonate works as a corticosteroid, inhibiting the release of inflammatory mediators (e.g., prostaglandins, leukotrienes), thereby reducing inflammation, swelling, and pain. Gatifloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Anti-inflammatory and antibacterial effects can be observed within minutes to hours after administration.
Excretion
Metabolites of Loteprednol are primarily excreted via urine. Unabsorbed Gatifloxacin is excreted unchanged, primarily through the kidneys.
Half life
Loteprednol Etabonate is rapidly metabolized to inactive compounds. Gatifloxacin's ocular half-life is not precisely defined but sustains therapeutic concentrations locally.
Absorption
Systemic absorption of both Loteprednol Etabonate and Gatifloxacin from ocular administration is minimal. Loteprednol is designed for localized action with rapid metabolism to inactive forms.
Metabolism
Loteprednol Etabonate undergoes rapid metabolism via ester hydrolysis to inactive carboxylic acid metabolites. Gatifloxacin is minimally metabolized.
Side Effects
Contraindications
- Hypersensitivity to any component of the medication or to other quinolones or corticosteroids.
- Acute untreated purulent bacterial infections of the eye, viral diseases of the cornea and conjunctiva (including epithelial herpes simplex keratitis, vaccinia, varicella), mycobacterial infection of the eye, and fungal diseases of ocular structures.
Drug Interactions
Systemic interactions
Minimal systemic absorption, so clinically significant systemic drug interactions are unlikely.
Other ophthalmic preparations
If using other ophthalmic medications, wait at least 5-10 minutes between applications to prevent wash-out.
Storage
Store at room temperature (15-30°C). Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Overdose is unlikely with topical ophthalmic administration. If accidentally ingested, supportive measures may be necessary. Contact a poison control center or seek medical attention if symptoms occur.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when administered to a nursing mother. Consult your doctor before use.
Side Effects
Contraindications
- Hypersensitivity to any component of the medication or to other quinolones or corticosteroids.
- Acute untreated purulent bacterial infections of the eye, viral diseases of the cornea and conjunctiva (including epithelial herpes simplex keratitis, vaccinia, varicella), mycobacterial infection of the eye, and fungal diseases of ocular structures.
Drug Interactions
Systemic interactions
Minimal systemic absorption, so clinically significant systemic drug interactions are unlikely.
Other ophthalmic preparations
If using other ophthalmic medications, wait at least 5-10 minutes between applications to prevent wash-out.
Storage
Store at room temperature (15-30°C). Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Overdose is unlikely with topical ophthalmic administration. If accidentally ingested, supportive measures may be necessary. Contact a poison control center or seek medical attention if symptoms occur.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when administered to a nursing mother. Consult your doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months when unopened. Discard 28 days after opening.
Availability
Pharmacies, Hospitals, Clinics
Approval Status
Approved in various countries (prescription medicine)
Patent Status
Generic versions available
Clinical Trials
Clinical trials have demonstrated the efficacy and safety of Loteprednol Etabonate and Gatifloxacin combinations in treating ocular inflammatory and infectious conditions, showing superior outcomes compared to monotherapy in certain cases.
Lab Monitoring
- Intraocular pressure (IOP) monitoring during prolonged treatment (e.g., >10 days) with corticosteroids.
- Regular ophthalmologic examinations including slit lamp biomicroscopy.
Doctor Notes
- Emphasize the importance of shaking the bottle before use.
- Educate patients on potential risks of prolonged steroid use (e.g., IOP elevation, cataract formation).
- Advise against wearing contact lenses during treatment unless directed by the ophthalmologist.
Patient Guidelines
- Shake the bottle well before each use.
- Do not touch the dropper tip to any surface to avoid contamination.
- Remove contact lenses before applying drops and wait at least 15 minutes before reinserting them.
- Complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
This medication may cause temporary blurred vision or other visual disturbances. If this occurs, avoid driving or operating machinery until your vision clears.
Lifestyle Advice
- Maintain good eye hygiene to prevent further infection.
- Avoid rubbing your eyes, especially during treatment.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.