Lotepro-DS

Shake well before use. Instill drops into the conjunctival sac of the affected eye(s). Avoid touching the dropper tip to any surface to prevent contamination. If more than one ophthalmic drug is used, instill them at least 5 minutes apart.

Loteprednol etabonate is a corticosteroid that acts by binding to glucocorticoid receptors in the cytoplasm, leading to the formation of steroid-receptor complexes that translocate to the nucleus. This modulates gene expression, resulting in the inhibition of various inflammatory mediators such as prostaglandins, leukotrienes, and cytokines. Its 'soft' steroid nature means it is rapidly metabolized into inactive compounds after exerting its local therapeutic effects, thereby reducing the potential for systemic side effects.

• Most viral diseases of the cornea and conjunctiva, including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella.
• Mycobacterial infection of the eye.
• Fungal diseases of ocular structures.
• Hypersensitivity to any component of the medication or to other corticosteroids.

Store upright at room temperature (15°-25°C or 59°-77°F). Protect from freezing. Keep out of reach of children.

An acute overdose with ophthalmic administration is unlikely to lead to systemic toxicity due to the limited absorption. If accidentally ingested, symptomatic and supportive measures should be taken.

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether topical ocular administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk. Caution should be exercised when administered to a nursing mother.

• Most viral diseases of the cornea and conjunctiva, including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella.
• Mycobacterial infection of the eye.
• Fungal diseases of ocular structures.
• Hypersensitivity to any component of the medication or to other corticosteroids.

Store upright at room temperature (15°-25°C or 59°-77°F). Protect from freezing. Keep out of reach of children.

An acute overdose with ophthalmic administration is unlikely to lead to systemic toxicity due to the limited absorption. If accidentally ingested, symptomatic and supportive measures should be taken.

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether topical ocular administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk. Caution should be exercised when administered to a nursing mother.