Lucon
Generic Name
Fluconazole
Manufacturer
Many manufacturers (e.g., Pfizer, Square, Beximco)
Country
Global (manufactured in many countries)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lucon 50 mg capsule | ৳ 8.06 | ৳ 80.58 |
| lucon 150 mg capsule | ৳ 22.15 | ৳ 221.45 |
Description
Overview of the medicine
Lucon (Fluconazole) is an antifungal medication used for a variety of fungal infections, including vaginal candidiasis, oral thrush, esophageal candidiasis, and systemic fungal infections. It belongs to the triazole class of antifungals.
Uses & Indications
Dosage
Adults
Vaginal candidiasis: 150 mg single oral dose. Oropharyngeal candidiasis: 50-200 mg once daily for 7-14 days. Systemic candidiasis: 400 mg on day 1, then 200-400 mg daily.
Elderly
Dosage adjustment not usually required unless renal function is impaired. Use lowest effective dose.
Renal_impairment
Dosage adjustment needed for creatinine clearance <50 mL/min (e.g., 50% of recommended dose after loading dose).
How to Take
Oral capsules/tablets can be taken with or without food. Oral suspension should be shaken well before use. IV infusion should be administered slowly, typically at a rate not exceeding 200 mg per hour.
Mechanism of Action
Fluconazole inhibits the fungal cytochrome P450 enzyme 14α-demethylase, which is responsible for the demethylation of lanosterol to ergosterol. Ergosterol is a vital component of the fungal cell membrane, and its impaired synthesis leads to increased cell permeability and eventual cell lysis.
Pharmacokinetics
Onset
Clinical improvement usually within 2-3 days for candidiasis.
Excretion
Mainly renal (80% unchanged drug, 11% as metabolites).
Half life
Approximately 30 hours (range 20-50 hours).
Absorption
Well absorbed orally, bioavailability >90%. Peak plasma concentrations within 1-2 hours.
Metabolism
Minimally metabolized (approx. 11% by CYP2C9); primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to fluconazole or other azole antifungals
- Co-administration with terfenadine, astemizole, cisapride, pimozide, quinidine, or erythromycin (due to risk of QT prolongation and arrhythmias)
- Severe hepatic impairment
Drug Interactions
Statins
Increased statin levels, risk of myopathy/rhabdomyolysis.
Warfarin
Increased anticoagulant effect, monitor INR.
Phenytoin
Increased phenytoin levels, monitor.
Rifampicin
Decreased fluconazole levels.
Benzodiazepines (e.g., midazolam)
Increased benzodiazepine levels, potentiated sedative effects.
Oral Hypoglycemics (sulfonylureas)
Increased plasma concentrations, risk of hypoglycemia.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children. Do not freeze oral suspension.
Overdose
Symptoms include hallucinations and paranoid behavior. Treatment is symptomatic and supportive, possibly gastric lavage and forced diuresis to accelerate excretion.
Pregnancy & Lactation
Pregnancy Category C (single dose for vaginal candidiasis); D (high doses/long-term use) for non-life-threatening indications due to potential teratogenic effects. Use with caution during lactation as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months, depending on formulation and manufacturer.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by FDA and DGDA
Patent Status
Generic available (original patent expired)
WHO Essential Medicine
YesClinical Trials
Fluconazole has been extensively studied in numerous clinical trials for various superficial and systemic fungal infections, demonstrating high efficacy and an acceptable safety profile. Studies have confirmed its effectiveness in conditions like vaginal candidiasis, cryptococcal meningitis, and oropharyngeal candidiasis.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) especially in patients with pre-existing hepatic impairment or prolonged therapy.
- Renal function tests (serum creatinine, BUN).
- Electrolytes, particularly potassium, in patients at risk of QT prolongation.
Doctor Notes
- Counsel patients on importance of completing full course to prevent recurrence and resistance.
- Monitor liver function tests periodically for long-term therapy, especially in patients with pre-existing hepatic disease.
- Be aware of potential drug interactions, particularly with CYP2C9 and CYP3A4 substrates, and adjust concomitant medications as necessary.
- Consider dose adjustment in renal impairment.
Patient Guidelines
- Complete the full course of medication as prescribed, even if symptoms improve, to prevent recurrence and resistance.
- Report any severe skin reactions, yellowing of skin/eyes, dark urine, or unusual fatigue immediately.
- Inform your doctor about all other medications, herbal products, and supplements you are taking.
- Do not share this medication with others.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or seizures in rare cases; caution advised when driving or operating machinery until you know how this medication affects you.
Lifestyle Advice
- Maintain good personal hygiene to prevent recurrence of fungal infections, especially in warm, moist areas.
- Avoid sharing personal items (towels, clothing, shoes) to prevent spreading infection.
- Wear breathable clothing and footwear.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.