Lumexit
Generic Name
Lumazepam
Manufacturer
PharmaCorp Bangladesh Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lumexit 05 mg tablet | ৳ 4.00 | ৳ 56.00 |
Description
Overview of the medicine
Lumexit 0.5 mg Tablet contains Lumazepam, a benzodiazepine derivative. It is primarily used for the short-term management of anxiety disorders and related symptoms.
Uses & Indications
Dosage
Adults
Initial dose 0.5 mg, 2 to 3 times daily. May be increased to 1-2 mg, 2 to 3 times daily, based on patient response and tolerability. Max daily dose typically 6 mg.
Elderly
Initiate with a lower dose, e.g., 0.25 mg, 1 to 2 times daily, and adjust carefully due to increased sensitivity and slower elimination.
Renal_impairment
Use with caution. Dosage reduction may be necessary in severe impairment. Monitor for sedation.
How to Take
Lumexit tablets should be taken orally with water, with or without food. Do not crush or chew the tablet.
Mechanism of Action
Lumazepam enhances the effect of gamma-aminobutyric acid (GABA) at the GABA-A receptor, leading to increased chloride ion influx, hyperpolarization, and decreased neuronal excitability in the central nervous system.
Pharmacokinetics
Onset
Onset of action typically within 30-60 minutes.
Excretion
Excreted mainly in the urine as inactive metabolites.
Half life
Elimination half-life ranges from 10-20 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver via glucuronidation and oxidative pathways.
Side Effects
Contraindications
- Hypersensitivity to Lumazepam or any benzodiazepine
- Acute narrow-angle glaucoma
- Severe respiratory insufficiency
- Severe hepatic insufficiency
- Myasthenia gravis
- Sleep apnea syndrome
Drug Interactions
Opioids
Significantly increased risk of profound sedation, respiratory depression, coma, and death.
Antacids
May delay absorption of Lumazepam.
Alcohol and other CNS Depressants
Increased risk of sedation, respiratory depression, and hypotension.
CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin)
May increase Lumazepam plasma concentrations and enhance its effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, impaired coordination, diminished reflexes, and coma. Management involves supportive care, maintaining airway, monitoring vital signs, and if severe, administration of flumazenil (a benzodiazepine receptor antagonist).
Pregnancy & Lactation
Pregnancy Category D. Should be avoided during pregnancy due to potential for fetal harm. Excreted in breast milk and may cause sedation in the infant; therefore, not recommended during lactation.
Side Effects
Contraindications
- Hypersensitivity to Lumazepam or any benzodiazepine
- Acute narrow-angle glaucoma
- Severe respiratory insufficiency
- Severe hepatic insufficiency
- Myasthenia gravis
- Sleep apnea syndrome
Drug Interactions
Opioids
Significantly increased risk of profound sedation, respiratory depression, coma, and death.
Antacids
May delay absorption of Lumazepam.
Alcohol and other CNS Depressants
Increased risk of sedation, respiratory depression, and hypotension.
CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin)
May increase Lumazepam plasma concentrations and enhance its effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, impaired coordination, diminished reflexes, and coma. Management involves supportive care, maintaining airway, monitoring vital signs, and if severe, administration of flumazenil (a benzodiazepine receptor antagonist).
Pregnancy & Lactation
Pregnancy Category D. Should be avoided during pregnancy due to potential for fetal harm. Excreted in breast milk and may cause sedation in the infant; therefore, not recommended during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
Clinical Trials
Clinical trials have demonstrated Lumazepam's efficacy in reducing anxiety symptoms and improving sleep in patients with anxiety disorders. Studies also focused on its pharmacokinetic profile and safety.
Lab Monitoring
- Liver function tests (periodically during long-term therapy)
- Renal function tests (in patients with kidney impairment)
Doctor Notes
- Emphasize the short-term use of Lumazepam to minimize dependence risks.
- Advise patients on gradual tapering when discontinuing treatment to avoid withdrawal symptoms.
- Monitor for signs of respiratory depression, especially with concomitant use of opioids or other CNS depressants.
- Assess for abuse potential before and during therapy.
Patient Guidelines
- Do not stop taking Lumexit suddenly, as this may lead to withdrawal symptoms.
- Avoid alcohol and other CNS depressants while on this medication.
- Report any unusual or severe side effects to your doctor.
- Use for the shortest duration possible.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Lumexit can cause drowsiness, dizziness, and impaired coordination. Patients should avoid driving or operating dangerous machinery until they know how the medication affects them.
Lifestyle Advice
- Avoid activities requiring mental alertness, such as driving or operating heavy machinery.
- Consider stress-reduction techniques and good sleep hygiene.
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