Lumiface
Generic Name
Fluticasone Propionate 0.005% Cream
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lumiface 0005 cream | ৳ 250.00 | N/A |
Description
Overview of the medicine
Lumiface-0005-Cream is a topical corticosteroid cream containing Fluticasone Propionate 0.005% w/w. It is used to reduce inflammation and itching associated with various skin conditions.
Uses & Indications
Dosage
Adults
Apply a thin film to the affected skin areas once or twice daily, as directed by the physician. Do not use for more than 4 weeks without medical review.
Elderly
Same as adult dosage. Use with caution due to potential for thinner skin and increased systemic absorption.
Renal_impairment
No specific dose adjustment required for topical application, as systemic absorption is minimal.
How to Take
For external use only. Apply a thin layer to the affected area and rub in gently. Wash hands before and after application. Avoid contact with eyes, mouth, and mucous membranes.
Mechanism of Action
Fluticasone Propionate is a synthetic trifluorinated corticosteroid with potent anti-inflammatory, antipruritic, and vasoconstrictive properties. It acts by inducing phospholipase A2 inhibitory proteins, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
Pharmacokinetics
Onset
Relief from symptoms can be observed within a few days of consistent application.
Excretion
Excreted primarily in feces, with a minor portion excreted in urine.
Half life
Systemic half-life is approximately 1-2 hours for absorbed drug, but local effects persist longer.
Absorption
Minimal systemic absorption through intact skin. Absorption increases with occlusion, skin integrity compromise, or application to large surface areas.
Metabolism
Primarily metabolized in the liver via CYP3A4 pathway.
Side Effects
Contraindications
- Hypersensitivity to fluticasone propionate or any component of the cream.
- Rosacea, acne vulgaris, perioral dermatitis.
- Pruritus without inflammation.
- Primary cutaneous viral infections (e.g., herpes simplex, varicella).
- Primary cutaneous fungal or bacterial infections.
- Diaper rash.
Drug Interactions
CYP3A4 inhibitors
Although systemic absorption is minimal, potent CYP3A4 inhibitors (e.g., ritonavir, ketoconazole) may increase systemic exposure, particularly with prolonged use or application to large areas.
Corticosteroid-containing products
Concurrent use of other corticosteroid-containing products may increase systemic absorption and risk of side effects.
Storage
Store below 30°C. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely due to minimal systemic absorption. Chronic overdose or misuse may lead to hypercortisolism (Cushing's syndrome) and adrenal suppression. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Caution advised during lactation; minimize use and avoid application to the breast area.
Side Effects
Contraindications
- Hypersensitivity to fluticasone propionate or any component of the cream.
- Rosacea, acne vulgaris, perioral dermatitis.
- Pruritus without inflammation.
- Primary cutaneous viral infections (e.g., herpes simplex, varicella).
- Primary cutaneous fungal or bacterial infections.
- Diaper rash.
Drug Interactions
CYP3A4 inhibitors
Although systemic absorption is minimal, potent CYP3A4 inhibitors (e.g., ritonavir, ketoconazole) may increase systemic exposure, particularly with prolonged use or application to large areas.
Corticosteroid-containing products
Concurrent use of other corticosteroid-containing products may increase systemic absorption and risk of side effects.
Storage
Store below 30°C. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely due to minimal systemic absorption. Chronic overdose or misuse may lead to hypercortisolism (Cushing's syndrome) and adrenal suppression. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Caution advised during lactation; minimize use and avoid application to the breast area.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies and Drugstores
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Fluticasone Propionate in various dermatoses.
Lab Monitoring
- No routine lab monitoring required for typical topical use. In cases of extensive or prolonged use, monitoring for adrenal suppression (e.g., plasma cortisol levels) may be considered.
Doctor Notes
- Educate patients on proper application technique and duration of use to minimize adverse effects.
- Monitor for signs of skin atrophy or systemic effects in patients on prolonged therapy.
Patient Guidelines
- Apply thinly and sparingly to the affected area.
- Do not use on the face, groin, or axillae unless directed by a physician.
- Avoid using occlusive dressings unless advised by a doctor.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose.
Driving Precautions
Lumiface-0005-Cream is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene.
- Avoid irritants that can worsen skin conditions.
- Follow physician's advice regarding duration of use strictly.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.