Luminor
Generic Name
Brimonidine Tartrate 0.025% Ophthalmic Solution
Manufacturer
Example Pharma Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| luminor 0025 eye drop | ৳ 115.00 | N/A |
Description
Overview of the medicine
Luminor-0025 Eye Drop contains Brimonidine Tartrate, an alpha-2 adrenergic agonist, used to lower elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. This specific formulation is designed for reduced systemic absorption.
Uses & Indications
Dosage
Adults
One drop in the affected eye(s) twice daily, approximately 12 hours apart.
Elderly
No dosage adjustment required for elderly patients, but caution is advised due to potential systemic effects.
Renal_impairment
Caution recommended in patients with severe renal impairment; use with careful monitoring.
How to Take
For ophthalmic use only. Tilt head back, pull down the lower eyelid to form a pouch. Gently squeeze the dropper to instill one drop, then close the eye. Apply light pressure to the tear duct for one minute to minimize systemic absorption. If using other eye drops, wait at least 5 minutes between applications.
Mechanism of Action
Brimonidine Tartrate is a relatively selective alpha-2 adrenergic agonist. It reduces intraocular pressure by decreasing aqueous humor production and increasing uveoscleral outflow. The exact mechanism for increasing uveoscleral outflow is not fully elucidated but involves complex physiological pathways.
Pharmacokinetics
Onset
Approximately 1-4 hours after administration.
Excretion
Mainly excreted renally as metabolites.
Half life
Approximately 2-3 hours systemically, but longer ocular retention.
Absorption
Minimal systemic absorption after ocular administration. Peak plasma concentration achieved within 1-4 hours.
Metabolism
Primarily metabolized in the liver via aldehyde oxidase. Also undergoes non-enzymatic metabolism.
Side Effects
Contraindications
- Hypersensitivity to Brimonidine Tartrate or any component of the formulation.
- Patients receiving monoamine oxidase (MAO) inhibitors.
- Neonates and infants (under 2 years of age).
Drug Interactions
MAO Inhibitors
Contraindicated. May result in an exaggerated hypotensive response.
CNS Depressants (e.g., alcohol, barbiturates, opioids, sedatives)
Potential for additive or potentiating effect. Use with caution.
Beta-blockers (ocular and systemic), Antihypertensives, Cardiac Glycosides
Potential for additive effects in lowering blood pressure and/or pulse. Use with caution.
Storage
Store at room temperature (below 30°C). Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Systemic overdose is unlikely due to minimal ocular absorption. However, symptoms of oral overdose in adults can include hypotension, bradycardia, drowsiness, and CNS depression. In children, severe CNS depression, bradycardia, apnea, and hypothermia have been reported. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. It is unknown whether Brimonidine is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Brimonidine Tartrate or any component of the formulation.
- Patients receiving monoamine oxidase (MAO) inhibitors.
- Neonates and infants (under 2 years of age).
Drug Interactions
MAO Inhibitors
Contraindicated. May result in an exaggerated hypotensive response.
CNS Depressants (e.g., alcohol, barbiturates, opioids, sedatives)
Potential for additive or potentiating effect. Use with caution.
Beta-blockers (ocular and systemic), Antihypertensives, Cardiac Glycosides
Potential for additive effects in lowering blood pressure and/or pulse. Use with caution.
Storage
Store at room temperature (below 30°C). Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Systemic overdose is unlikely due to minimal ocular absorption. However, symptoms of oral overdose in adults can include hypotension, bradycardia, drowsiness, and CNS depression. In children, severe CNS depression, bradycardia, apnea, and hypothermia have been reported. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. It is unknown whether Brimonidine is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months unopened. Use within 28 days after opening.
Availability
Pharmacies, hospitals, and clinics
Approval Status
Approved by FDA and local regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Brimonidine Tartrate in reducing intraocular pressure in patients with open-angle glaucoma and ocular hypertension. This 0.025% formulation specifically underwent trials to confirm its lower systemic absorption profile while maintaining efficacy.
Lab Monitoring
- Routine ophthalmic examinations to monitor intraocular pressure.
- Periodic assessment for systemic side effects, especially cardiovascular and CNS effects, particularly in at-risk patients.
Doctor Notes
- Emphasize proper instillation technique to patients.
- Monitor for signs of allergic conjunctivitis or systemic side effects.
- Counsel patients on potential for drowsiness or fatigue.
Patient Guidelines
- Do not touch the dropper tip to any surface to avoid contamination.
- Remove contact lenses before application and wait at least 15 minutes before reinserting them.
- Do not use if the solution changes color or becomes cloudy.
Missed Dose Advice
If a dose is missed, apply it as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause blurred vision, drowsiness, or fatigue. Exercise caution when driving or operating machinery, especially after instillation. If these symptoms occur, avoid such activities.
Lifestyle Advice
- Regularly attend eye check-ups as advised by your doctor.
- Maintain good ocular hygiene.
- Inform your doctor about all medications you are taking, including over-the-counter drugs and herbal supplements.
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