Lupred
Generic Name
Prednisolone Acetate Ophthalmic Suspension 0.5%
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lupred 005 eye drop | ৳ 180.00 | N/A |
Description
Overview of the medicine
Lupred 0.5% Eye Drop contains Prednisolone Acetate, an ophthalmic corticosteroid, used to treat inflammatory conditions of the eye, such as allergic conjunctivitis, uveitis, and post-operative inflammation. It reduces swelling, redness, and itching.
Uses & Indications
Dosage
Adults
Instill 1-2 drops into the conjunctival sac 2-4 times daily. In severe cases, dosage may be increased to 1-2 drops every hour until improvement, then gradually tapered.
Elderly
No specific dosage adjustment required for elderly patients.
Renal_impairment
No specific dosage adjustment required.
How to Take
For ophthalmic use only. Shake well before use. Do not touch the dropper tip to any surface to avoid contamination. Apply pressure to the tear duct for one minute after administration to reduce systemic absorption.
Mechanism of Action
Prednisolone Acetate acts by inhibiting the release of inflammatory mediators and suppressing the immune response. It reduces capillary permeability and leukocyte migration, thereby decreasing inflammation, swelling, and pain in the eye.
Pharmacokinetics
Onset
Anti-inflammatory effects typically begin within a few hours.
Excretion
Primarily excreted in urine if systemically absorbed.
Half life
Not well-defined for ophthalmic use due to minimal systemic absorption; local effects persist for several hours.
Absorption
Minimal systemic absorption occurs after ophthalmic administration. Local ocular absorption is effective.
Metabolism
Metabolized primarily in the liver if systemically absorbed, but local metabolism in ocular tissues may occur.
Side Effects
Contraindications
- Acute untreated purulent ocular infections
- Acute superficial herpes simplex keratitis
- Fungal diseases of ocular structures
- Vaccinia, varicella, and most other viral diseases of the cornea and conjunctiva
- Hypersensitivity to any component of the medication
Drug Interactions
Anticholinergics
May increase intraocular pressure when used with corticosteroids.
NSAIDs (topical)
Concomitant use with topical NSAIDs may increase the potential for corneal healing problems.
Storage
Store upright at controlled room temperature (15-30°C). Protect from light and freezing. Keep out of reach of children.
Overdose
Ophthalmic overdose is unlikely to cause systemic toxicity due to limited systemic absorption. If accidentally ingested, symptomatic and supportive measures should be taken.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in human milk, use with caution in nursing mothers.
Side Effects
Contraindications
- Acute untreated purulent ocular infections
- Acute superficial herpes simplex keratitis
- Fungal diseases of ocular structures
- Vaccinia, varicella, and most other viral diseases of the cornea and conjunctiva
- Hypersensitivity to any component of the medication
Drug Interactions
Anticholinergics
May increase intraocular pressure when used with corticosteroids.
NSAIDs (topical)
Concomitant use with topical NSAIDs may increase the potential for corneal healing problems.
Storage
Store upright at controlled room temperature (15-30°C). Protect from light and freezing. Keep out of reach of children.
Overdose
Ophthalmic overdose is unlikely to cause systemic toxicity due to limited systemic absorption. If accidentally ingested, symptomatic and supportive measures should be taken.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Prednisolone is excreted in human milk, use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months. Discard 28 days after opening.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic, patent expired
WHO Essential Medicine
YesClinical Trials
Prednisolone Acetate has been extensively studied in various clinical trials demonstrating its efficacy and safety for ocular inflammatory conditions. Post-marketing surveillance continues to monitor its long-term effects.
Lab Monitoring
- Regular intraocular pressure (IOP) monitoring during prolonged treatment.
- Periodic slit-lamp examination.
Doctor Notes
- Advise patients about the importance of not discontinuing treatment prematurely.
- Monitor intraocular pressure regularly, especially in patients on prolonged therapy.
- Caution in patients with corneal ulcers or other conditions leading to corneal thinning.
Patient Guidelines
- Do not wear contact lenses during treatment with this medicine unless advised by your doctor.
- Do not discontinue abruptly, especially after prolonged use; follow doctor's advice for tapering.
- Report any signs of infection or irritation to your doctor immediately.
- Shake the bottle well before each use.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause temporary blurred vision. Avoid driving or operating machinery until vision is clear.
Lifestyle Advice
- Avoid rubbing your eyes.
- Maintain good hand hygiene before and after applying eye drops.
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Global Brand Names
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