Luvio
Generic Name
Fluoxetine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| luvio 60 mg capsule | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Luvio 60 mg Capsule contains Fluoxetine, an antidepressant medication used to treat major depressive disorder, obsessive-compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. It helps improve mood, sleep, appetite, and energy level and decrease anxiety and fear.
Uses & Indications
Dosage
Adults
For Bulimia Nervosa: 60 mg orally once daily. For Major Depressive Disorder, OCD, Panic Disorder: Initial 20 mg/day, gradually increased; maximum 60 mg/day. PMDD: 20 mg/day continuously or intermittently.
Elderly
Lower initial doses may be considered, usually 10-20 mg/day, with gradual titration. Maximum 60 mg/day.
Renal_impairment
No dose adjustment necessary for mild to moderate impairment. Use with caution in severe impairment.
How to Take
Take orally once daily, with or without food. It is generally recommended to take it in the morning to avoid insomnia.
Mechanism of Action
Fluoxetine selectively inhibits the reuptake of serotonin (5-HT) in the central nervous system, thereby potentiating serotonergic activity.
Pharmacokinetics
Onset
Clinical effects typically observed within 2-4 weeks, though some patients may experience benefits earlier.
Excretion
Primarily excreted by the kidneys (approx. 60%) as metabolites, with a small amount in feces.
Half life
Fluoxetine has a relatively long half-life of 2-4 days, and its active metabolite, norfluoxetine, has an even longer half-life of 4-16 days.
Absorption
Well absorbed orally. Peak plasma concentrations reached within 6-8 hours. Food does not affect bioavailability but may delay absorption.
Metabolism
Extensively metabolized in the liver by CYP2D6 to norfluoxetine, an active metabolite.
Side Effects
Contraindications
- Concomitant use with MAOIs (Monoamine Oxidase Inhibitors) or within 14 days of discontinuing an MAOI
- Concomitant use with Thioridazine or Pimozide
- Hypersensitivity to Fluoxetine or any component of the formulation
Drug Interactions
MAOIs
Risk of serious, sometimes fatal, reactions including serotonin syndrome.
Warfarin, NSAIDs
Increased risk of bleeding due to effects on platelet function.
Thioridazine, Pimozide
Risk of QT prolongation and cardiac arrhythmias.
Tryptophan, St. John's Wort
Increased risk of serotonin syndrome.
Tricyclic Antidepressants (TCAs)
May increase plasma levels of TCAs, requiring dose adjustment.
Storage
Store below 30°C in a dry place, away from light.
Overdose
Symptoms include nausea, vomiting, seizures, serotonin syndrome (agitation, hallucinations, rapid heart beat, fever, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination), and coma. Management involves supportive care, maintaining airway, monitoring cardiac and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Fluoxetine is excreted in breast milk; caution should be exercised.
Side Effects
Contraindications
- Concomitant use with MAOIs (Monoamine Oxidase Inhibitors) or within 14 days of discontinuing an MAOI
- Concomitant use with Thioridazine or Pimozide
- Hypersensitivity to Fluoxetine or any component of the formulation
Drug Interactions
MAOIs
Risk of serious, sometimes fatal, reactions including serotonin syndrome.
Warfarin, NSAIDs
Increased risk of bleeding due to effects on platelet function.
Thioridazine, Pimozide
Risk of QT prolongation and cardiac arrhythmias.
Tryptophan, St. John's Wort
Increased risk of serotonin syndrome.
Tricyclic Antidepressants (TCAs)
May increase plasma levels of TCAs, requiring dose adjustment.
Storage
Store below 30°C in a dry place, away from light.
Overdose
Symptoms include nausea, vomiting, seizures, serotonin syndrome (agitation, hallucinations, rapid heart beat, fever, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination), and coma. Management involves supportive care, maintaining airway, monitoring cardiac and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Fluoxetine is excreted in breast milk; caution should be exercised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Fluoxetine has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of major depressive disorder, OCD, bulimia nervosa, panic disorder, and PMDD across various patient populations.
Lab Monitoring
- Monitor for serum sodium levels (especially in elderly or volume-depleted patients)
- Monitor liver function tests periodically (in patients with pre-existing hepatic impairment)
- Monitor ECG in patients with cardiac risk factors (due to potential for QT prolongation)
Doctor Notes
- Emphasize the importance of adherence to treatment and not stopping abruptly.
- Counsel patients on potential delayed onset of action and management of initial side effects.
- Screen for bipolar disorder before initiating therapy to avoid precipitating mania/hypomania.
Patient Guidelines
- Do not stop taking this medicine suddenly without consulting your doctor, as withdrawal symptoms may occur.
- It may take several weeks to feel the full benefits; continue as prescribed.
- Report any unusual mood changes, worsening depression, or suicidal thoughts to your doctor immediately.
- Avoid alcohol while taking this medication.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness, drowsiness, or blurred vision. Avoid driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Engage in regular physical activity.
- Maintain a balanced diet.
- Practice stress-reduction techniques like meditation or yoga.
- Ensure adequate sleep.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.