Lyca-CR
Generic Name
Naproxen Controlled Release
Manufacturer
Hypothetical Pharma Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lyca cr 825 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Lyca-CR 825 mg Tablet is a controlled-release non-steroidal anti-inflammatory drug (NSAID) used for the long-term treatment of various inflammatory conditions and pain. Its controlled-release mechanism provides sustained relief over an extended period.
Uses & Indications
Dosage
Adults
Typically, one 825 mg tablet once daily for maintenance therapy. Dosage may be adjusted based on patient response and tolerability, not exceeding 1650 mg/day.
Elderly
Use with caution; lower doses may be required due to increased risk of adverse effects. Consider starting at 660 mg once daily.
Renal_impairment
Not recommended for patients with severe renal impairment (creatinine clearance < 30 mL/min). For moderate impairment, dose reduction may be necessary.
How to Take
Swallow the tablet whole with water. Do not chew, crush, or break the tablet, as this may affect the controlled-release mechanism. Can be taken with food or milk to minimize gastrointestinal upset.
Mechanism of Action
Naproxen, like other NSAIDs, exerts its anti-inflammatory, analgesic, and antipyretic effects primarily by inhibiting prostaglandin synthesis through the non-selective inhibition of cyclooxygenase (COX-1 and COX-2) enzymes. COX-1 is involved in maintaining normal physiological functions, while COX-2 is induced during inflammation.
Pharmacokinetics
Onset
Pain relief typically starts within 1-2 hours, with full anti-inflammatory effects taking longer (days to weeks).
Excretion
Mainly excreted in the urine (95%) as metabolites and conjugates, with a small amount excreted in the feces.
Half life
Approximately 12-17 hours.
Absorption
Well absorbed from the gastrointestinal tract. Peak plasma levels for controlled-release formulations are achieved in 6-12 hours.
Metabolism
Extensively metabolized in the liver by demethylation and subsequent conjugation.
Side Effects
Contraindications
- Hypersensitivity to naproxen or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure
- Severe renal impairment
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery
Drug Interactions
Lithium
Increased lithium plasma levels, potentially leading to toxicity.
SSRIs/SNRIs
Increased risk of GI bleeding.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of GI ulceration or bleeding.
ACE inhibitors/ARBs
Reduced antihypertensive effect; increased risk of renal impairment.
Warfarin, anticoagulants
Increased risk of bleeding.
Diuretics (e.g., Furosemide, Thiazides)
Reduced natriuretic effect; increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, nausea, vomiting, epigastric pain, and rarely, gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric emptying and activated charcoal may be considered if ingested recently. Hemodialysis is not effective in removing naproxen.
Pregnancy & Lactation
Pregnancy: Contraindicated in the third trimester due to the risk of premature closure of the fetal ductus arteriosus. Use in first and second trimesters should only be if clearly needed and the potential benefit outweighs the risk. Lactation: Naproxen is excreted in breast milk. Use is generally not recommended during breastfeeding due to potential adverse effects on the infant.
Side Effects
Contraindications
- Hypersensitivity to naproxen or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure
- Severe renal impairment
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery
Drug Interactions
Lithium
Increased lithium plasma levels, potentially leading to toxicity.
SSRIs/SNRIs
Increased risk of GI bleeding.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of GI ulceration or bleeding.
ACE inhibitors/ARBs
Reduced antihypertensive effect; increased risk of renal impairment.
Warfarin, anticoagulants
Increased risk of bleeding.
Diuretics (e.g., Furosemide, Thiazides)
Reduced natriuretic effect; increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, nausea, vomiting, epigastric pain, and rarely, gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric emptying and activated charcoal may be considered if ingested recently. Hemodialysis is not effective in removing naproxen.
Pregnancy & Lactation
Pregnancy: Contraindicated in the third trimester due to the risk of premature closure of the fetal ductus arteriosus. Use in first and second trimesters should only be if clearly needed and the potential benefit outweighs the risk. Lactation: Naproxen is excreted in breast milk. Use is generally not recommended during breastfeeding due to potential adverse effects on the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available (original patent expired)
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of naproxen in various inflammatory and painful conditions, including specific trials for controlled-release formulations demonstrating sustained drug levels and clinical benefits.
Lab Monitoring
- Complete Blood Count (CBC)
- Renal function tests (Creatinine, BUN)
- Liver function tests (ALT, AST)
- Blood pressure monitoring
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Monitor for signs and symptoms of GI bleeding or cardiovascular events, especially in high-risk patients.
- Assess renal function regularly, particularly in elderly or renally impaired patients.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not take more than the recommended dose.
- Report any signs of unusual bleeding, severe stomach pain, or black, tarry stools immediately.
- Avoid alcohol while taking this medication.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medication may cause dizziness, drowsiness, or visual disturbances. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet.
- Stay hydrated.
- Engage in regular, moderate exercise, if appropriate for your condition.
- Avoid smoking and excessive alcohol consumption.
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