Lyric CR
Generic Name
Pregabalin (Controlled Release)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| lyric cr 825 mg tablet | ৳ 25.00 | ৳ 250.00 |
Description
Overview of the medicine
Lyric CR 82.5 mg tablet contains Pregabalin in a controlled-release formulation. It is used to treat neuropathic pain, fibromyalgia, and as an adjunctive therapy for partial-onset seizures in adults. The controlled-release design allows for once-daily dosing.
Uses & Indications
Dosage
Adults
Starting dose usually 82.5 mg once daily. May be increased to 165 mg once daily after 1 week based on response and tolerability, up to a maximum of 330 mg once daily.
Elderly
Dosage adjustment may be required due to age-related decrease in renal function. Start with lower doses.
Renal_impairment
Dose reduction is necessary based on creatinine clearance. For CrCl 30-60 mL/min, maximum dose 165 mg/day; for CrCl 15-30 mL/min, maximum dose 82.5 mg/day.
How to Take
Take orally, once daily, with or without food. Swallow the tablet whole; do not crush, chew, or break it.
Mechanism of Action
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of several excitatory neurotransmitters. This leads to its analgesic, anxiolytic, and anticonvulsant effects.
Pharmacokinetics
Onset
Pain relief may be noticed within 1 week of starting treatment; full effect may take longer.
Excretion
Primarily excreted unchanged in the urine (approximately 98%).
Half life
Approximately 6.3 hours (for immediate release; CR formulation provides sustained plasma levels).
Absorption
Well-absorbed orally. Bioavailability is >90%. Controlled-release formulation provides prolonged absorption. Peak plasma concentration reached in 3-4 hours after CR dosing.
Metabolism
Negligible hepatic metabolism; less than 0.1% of the dose is metabolized in humans.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any of the excipients.
Drug Interactions
Thiazolidinedione Antidiabetics (e.g., rosiglitazone)
May increase the risk of weight gain and peripheral edema when used with pregabalin.
CNS Depressants (e.g., alcohol, benzodiazepines, opioids)
May enhance the CNS depressant effects of pregabalin, leading to increased somnolence and dizziness. Concomitant use should be with caution.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and, rarely, coma. Treatment is supportive and symptomatic. Hemodialysis can remove pregabalin from the plasma.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any of the excipients.
Drug Interactions
Thiazolidinedione Antidiabetics (e.g., rosiglitazone)
May increase the risk of weight gain and peripheral edema when used with pregabalin.
CNS Depressants (e.g., alcohol, benzodiazepines, opioids)
May enhance the CNS depressant effects of pregabalin, leading to increased somnolence and dizziness. Concomitant use should be with caution.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and, rarely, coma. Treatment is supportive and symptomatic. Hemodialysis can remove pregabalin from the plasma.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from the date of manufacture, depending on storage conditions.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generically available (original patent expired, CR formulations may have specific patents)
Clinical Trials
Pregabalin has undergone extensive clinical trials supporting its efficacy and safety for approved indications, including controlled-release formulations.
Lab Monitoring
- No routine laboratory monitoring is required. Renal function should be assessed, particularly in elderly patients or those with known renal impairment.
Doctor Notes
- Emphasize gradual titration of dose to minimize adverse effects.
- Counsel patients on potential for dizziness and somnolence, especially during initiation.
- Advise on renal dose adjustments for elderly and renally impaired patients.
- Monitor for signs of suicidal ideation or unusual behavioral changes.
Patient Guidelines
- Do not stop taking the medicine abruptly; dosage should be tapered gradually to avoid withdrawal symptoms.
- Inform your doctor if you experience any changes in mood, behavior, or suicidal thoughts.
- Avoid alcohol while taking this medicine.
- Do not drive or operate heavy machinery until you know how this medicine affects you.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness, somnolence, and blurred vision. Patients should be advised not to drive or operate complex machinery until they are reasonably certain that pregabalin does not adversely affect their ability to perform such activities.
Lifestyle Advice
- Avoid consuming alcohol. Be cautious with activities requiring mental alertness, such as driving or operating machinery, especially when initiating therapy or after dose adjustments.
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