Maclo
Generic Name
Aceclofenac 100 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| maclo 100 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Maclo 100 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Uses & Indications
Dosage
Adults
100 mg twice daily, preferably with or after food.
Elderly
No dosage adjustment is generally required, but caution is advised, and the lowest effective dose should be used.
Renal_impairment
No dosage adjustment is usually necessary for mild renal impairment, but caution is advised. Not recommended in severe renal impairment.
How to Take
Take orally with a glass of water, preferably with or after food to minimize gastrointestinal upset.
Mechanism of Action
Aceclofenac works by inhibiting the synthesis of prostaglandins, which are chemicals in the body that cause pain and inflammation. It primarily inhibits cyclooxygenase (COX) enzymes.
Pharmacokinetics
Onset
Analgesic effect usually starts within 1 hour.
Excretion
Approximately two-thirds of the dose is excreted in the urine and one-third in the faeces.
Half life
Approximately 4 hours.
Absorption
Well absorbed orally, peak plasma concentrations reached in 1.25-3 hours.
Metabolism
Extensively metabolized in the liver, primarily via CYP2C9, to 4'-hydroxyaceclofenac and other metabolites.
Side Effects
Contraindications
- Hypersensitivity to aceclofenac or other NSAIDs (e.g., aspirin)
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding. Management is symptomatic and supportive. Gastric lavage and activated charcoal may be considered within one hour of ingestion.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to potential fetal harm. Use with caution during the first two trimesters only if the potential benefit outweighs the risk. Not recommended during breastfeeding as aceclofenac may pass into breast milk.
Side Effects
Contraindications
- Hypersensitivity to aceclofenac or other NSAIDs (e.g., aspirin)
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding. Management is symptomatic and supportive. Gastric lavage and activated charcoal may be considered within one hour of ingestion.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to potential fetal harm. Use with caution during the first two trimesters only if the potential benefit outweighs the risk. Not recommended during breastfeeding as aceclofenac may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
DGDA Approved
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have demonstrated the efficacy and safety of aceclofenac in various inflammatory and painful conditions, supporting its use as an NSAID.
Lab Monitoring
- Renal function tests (serum creatinine, BUN) periodically, especially in elderly or patients with renal impairment.
- Liver function tests (ALT, AST) periodically during long-term therapy.
- Complete blood count (CBC) to monitor for gastrointestinal bleeding, especially with long-term use.
- Blood pressure monitoring, particularly at the start of treatment.
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Monitor for signs of gastrointestinal bleeding, renal dysfunction, and cardiovascular adverse events.
- Counsel patients on potential risks and symptoms requiring immediate medical attention.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose or duration of treatment.
- Report any unusual stomach pain, black stools, or blood in vomit to your doctor immediately.
- Avoid alcohol while taking this medicine.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances. If you experience these symptoms, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet and stay hydrated.
- Avoid excessive alcohol consumption.
- Regular exercise, if appropriate for your condition.
- Quit smoking to reduce cardiovascular risks.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.