Magacil Plus
Generic Name
Aluminum Hydroxide + Magnesium Hydroxide + Simethicone
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| magacil plus 480 mg suspension | ৳ 110.00 | N/A |
Description
Overview of the medicine
Magacil Plus 480 mg Suspension is an antacid and antiflatulent medication used to relieve symptoms of indigestion, heartburn, stomach upset, and gas. It works by neutralizing stomach acid and breaking up gas bubbles in the digestive tract.
Uses & Indications
Dosage
Adults
10-20 ml (2-4 teaspoonfuls) 3-4 times daily, between meals and at bedtime, or as directed by physician.
Elderly
Same as adult dosage, generally well tolerated.
Renal_impairment
Use with caution in severe renal impairment due to potential for magnesium accumulation.
How to Take
Shake bottle well before use. Take orally with or without water. Administer between meals and at bedtime for optimal effect.
Mechanism of Action
Aluminum hydroxide and magnesium hydroxide act as antacids by neutralizing hydrochloric acid in the stomach, reducing acidity. Simethicone is an antiflatulent agent that reduces surface tension of gas bubbles in the GI tract, causing them to coalesce and be more easily expelled.
Pharmacokinetics
Onset
Within 5-15 minutes (for antacid effect)
Excretion
Primarily excreted in feces; unabsorbed ions
Half life
Not applicable for active ingredients due to minimal systemic absorption
Absorption
Aluminum and magnesium are minimally absorbed from the gastrointestinal tract; Simethicone is not absorbed.
Metabolism
Not applicable due to minimal systemic absorption
Side Effects
Contraindications
- Hypersensitivity to any component
- Severe renal impairment
- Hypophosphatemia
Drug Interactions
Thyroid hormones
May reduce absorption. Administer at least 4 hours apart.
Tetracyclines, Fluoroquinolones, Digoxin, Iron salts
Antacids can reduce the absorption of these drugs. Separate administration by 2-4 hours.
Storage
Store below 30°C in a dry place, away from light. Do not freeze.
Overdose
Symptoms may include diarrhea, abdominal pain, nausea, vomiting. Management involves symptomatic and supportive care. In severe cases, electrolyte monitoring and correction may be needed.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation when used at recommended doses. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to any component
- Severe renal impairment
- Hypophosphatemia
Drug Interactions
Thyroid hormones
May reduce absorption. Administer at least 4 hours apart.
Tetracyclines, Fluoroquinolones, Digoxin, Iron salts
Antacids can reduce the absorption of these drugs. Separate administration by 2-4 hours.
Storage
Store below 30°C in a dry place, away from light. Do not freeze.
Overdose
Symptoms may include diarrhea, abdominal pain, nausea, vomiting. Management involves symptomatic and supportive care. In severe cases, electrolyte monitoring and correction may be needed.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation when used at recommended doses. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, drugstores, supermarkets
Approval Status
Approved by DGDA (Directorate General of Drug Administration, Bangladesh)
Patent Status
Generic/Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of aluminum hydroxide, magnesium hydroxide, and simethicone in treating gastric acid-related conditions and flatulence.
Lab Monitoring
- Serum phosphate levels (with prolonged use)
- Renal function (in patients with renal impairment)
- Serum magnesium levels (in patients with renal impairment or prolonged use)
Doctor Notes
- Advise patients on proper administration and potential drug interactions.
- Monitor renal function and electrolytes in high-risk patients.
- Educate patients on lifestyle modifications to manage indigestion.
Patient Guidelines
- Shake well before each use.
- Do not exceed recommended dose.
- Consult a doctor if symptoms persist for more than 2 weeks.
- Keep out of reach of children.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
No known effects on driving ability.
Lifestyle Advice
- Avoid trigger foods like spicy, fatty, acidic foods.
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
- Reduce stress.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.