Mantadin
Generic Name
Amantadine Hydrochloride
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mantadin 100 mg capsule | ৳ 10.00 | ৳ 140.00 |
Description
Overview of the medicine
Mantadin 100 mg Capsule contains Amantadine Hydrochloride, which is primarily used for the treatment of Parkinson's disease symptoms and drug-induced extrapyramidal reactions. It also has antiviral properties and is used for the prophylaxis and treatment of Influenza A virus infections.
Uses & Indications
Dosage
Adults
Parkinson's: 100 mg twice daily. Influenza A: 200 mg once daily or 100 mg twice daily. Maximum 400 mg/day.
Elderly
Generally lower doses, starting with 100 mg once daily, with careful titration due to potential for renal impairment and increased sensitivity.
Renal_impairment
Dose adjustment required. For CrCl 30-50 mL/min: 100 mg/day; For CrCl 15-29 mL/min: 100 mg every other day; For CrCl <15 mL/min: Not recommended or 100 mg weekly.
How to Take
Mantadin capsules should be taken orally, with or without food. It is generally recommended to take the last dose several hours before bedtime to avoid insomnia.
Mechanism of Action
Amantadine's antiparkinsonian effect is thought to be mediated by the release of dopamine from surviving dopaminergic neurons and blocking dopamine reuptake. It also has anticholinergic properties and acts as an NMDA receptor antagonist. Its antiviral action is due to interference with the function of the M2 protein, which is an ion channel specific to the influenza A virus.
Pharmacokinetics
Onset
Within 48 hours for antiparkinsonian effects; antiviral effects within hours of first dose.
Excretion
Excreted largely unchanged in the urine (primarily via glomerular filtration and tubular secretion).
Half life
Approximately 12-17 hours (range 9-30 hours); significantly prolonged in renal impairment.
Absorption
Readily absorbed from the gastrointestinal tract; peak plasma levels in 1-4 hours.
Metabolism
Minimally metabolized; 5-15% undergoes acetylation.
Side Effects
Contraindications
- Hypersensitivity to amantadine or any component of the formulation
- End-stage renal disease
- Severe congestive heart failure
- Untreated angle-closure glaucoma
Drug Interactions
CNS Stimulants
May increase CNS stimulation, leading to nervousness, insomnia, or seizures.
Anticholinergics
May enhance anticholinergic side effects (e.g., dry mouth, blurred vision, constipation).
Thiazide Diuretics/Triamterene
May reduce amantadine clearance, leading to increased plasma levels and toxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include cardiac arrhythmias, hypertension, seizures, agitation, hallucinations, and coma. Management involves gastric lavage, supportive care, and intravenous physostigmine for severe CNS symptoms.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Amantadine is excreted in breast milk; therefore, caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to amantadine or any component of the formulation
- End-stage renal disease
- Severe congestive heart failure
- Untreated angle-closure glaucoma
Drug Interactions
CNS Stimulants
May increase CNS stimulation, leading to nervousness, insomnia, or seizures.
Anticholinergics
May enhance anticholinergic side effects (e.g., dry mouth, blurred vision, constipation).
Thiazide Diuretics/Triamterene
May reduce amantadine clearance, leading to increased plasma levels and toxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include cardiac arrhythmias, hypertension, seizures, agitation, hallucinations, and coma. Management involves gastric lavage, supportive care, and intravenous physostigmine for severe CNS symptoms.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Amantadine is excreted in breast milk; therefore, caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
Clinical Trials
Extensively studied since its approval for efficacy in Parkinson's and Influenza A. Ongoing research sometimes explores new applications or formulations.
Lab Monitoring
- Renal function tests (especially in elderly or renally impaired patients)
- Blood pressure monitoring
Doctor Notes
- Assess renal function before initiating therapy and adjust dose accordingly.
- Monitor for neurological and psychiatric adverse effects, especially in elderly patients.
- Warn patients about the risk of sudden sleep onset and impulse control disorders.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking this medicine abruptly without consulting your doctor, as it can worsen Parkinsonian symptoms.
- Report any new or worsening side effects to your healthcare provider.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness, drowsiness, or blurred vision. Avoid driving or operating heavy machinery until you know how it affects you.
Lifestyle Advice
- Avoid sudden changes in posture (e.g., getting up too quickly) to minimize dizziness.
- Avoid or limit alcohol consumption while on this medication.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.