Oral tablets can be taken with or without food, typically in the morning to avoid nocturnal diuresis. Intravenous forms are administered by healthcare professionals.

Diuretics work by affecting different parts of the kidney's tubules to inhibit the reabsorption of sodium and chloride, which in turn leads to less water reabsorption and increased urine output. Loop diuretics (e.g., Furosemide) act on the loop of Henle, while thiazide diuretics (e.g., Hydrochlorothiazide) act on the distal convoluted tubule.

• •Anuria (absence of urine production)
• •Hypersensitivity to the drug or sulfonamide derivatives (for some diuretics)
• •Severe electrolyte depletion
• •Hepatic coma or precoma

Store at room temperature (below 30°C), protect from light and moisture. Keep out of reach of children.

Symptoms include severe dehydration, electrolyte imbalances (hypokalemia, hyponatremia, hypochloremia), hypotension, dizziness, and collapse. Management involves fluid and electrolyte replacement, and supportive care.

Generally avoided unless clearly indicated and benefits outweigh risks. Thiazide diuretics are generally considered safer than loop diuretics during pregnancy if needed. Consult a doctor.