Mapez
Generic Name
Montelukast
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mapez 3 mg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Mapez 3 mg Tablet contains Montelukast, a leukotriene receptor antagonist used for the prevention and long-term treatment of asthma and for the relief of symptoms of seasonal allergic rhinitis. It works by blocking leukotrienes, which are natural substances that cause narrowing and swelling of airways in the lungs, and also contribute to allergy symptoms.
Uses & Indications
Dosage
Adults
For children 2 to 5 years of age: 3 mg (chewable tablet) orally once daily in the evening. For asthma, this dose is recommended for patients aged 6 months to 5 years.
Elderly
Not applicable for this strength; elderly dosage for Montelukast is usually 10 mg.
Renal_impairment
No dosage adjustment necessary for patients with renal impairment.
How to Take
Take orally once daily in the evening. For chewable tablets, chew completely before swallowing. Can be taken with or without food. Continue treatment even if symptoms improve.
Mechanism of Action
Montelukast selectively inhibits the CysLT1 receptor, thereby blocking the action of leukotrienes (LTC4, LTD4, LTE4). Leukotrienes are potent inflammatory mediators released from various cells, including mast cells and eosinophils, and cause bronchoconstriction, increased vascular permeability, and inflammatory cell infiltration, which contribute to asthma and allergic rhinitis symptoms.
Pharmacokinetics
Onset
Clinical improvement may be seen within one day.
Excretion
Primarily excreted in feces via bile (approximately 86%), with less than 0.2% excreted in urine.
Half life
Approximately 2.7 to 5.5 hours.
Absorption
Rapidly absorbed after oral administration. Mean oral bioavailability is 64%.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4, CYP2C9, and CYP2C8.
Side Effects
Contraindications
- Hypersensitivity to montelukast or any component of the formulation.
- Acute asthma attacks (not indicated for rapid relief of acute bronchospasm).
Drug Interactions
Rifampin
May decrease montelukast plasma concentrations.
Gemfibrozil
May increase montelukast plasma concentrations.
Phenobarbital
May decrease montelukast levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Management is supportive and symptomatic; no specific antidote is known.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Montelukast is excreted in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available (original patent expired)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated Montelukast's efficacy and safety in the long-term management of asthma and treatment of allergic rhinitis across various age groups, including pediatric populations. Specific trials supported its use in children as young as 6 months.
Lab Monitoring
- No routine laboratory monitoring is required for montelukast. Liver function tests may be considered if symptoms of hepatic dysfunction develop.
Doctor Notes
- Emphasize to parents/caregivers that this is a prophylactic agent, not a rescue medication.
- Monitor for any behavioral changes or mood disturbances, especially in pediatric patients, and educate caregivers on this risk.
- Ensure proper administration, especially for chewable tablets, to maximize efficacy.
Patient Guidelines
- Take this medication exactly as prescribed.
- Do not stop taking it without consulting your doctor, even if you feel better.
- This medicine is not for sudden asthma attacks; use your rescue inhaler for acute symptoms.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Montelukast may cause dizziness or drowsiness in some individuals. Patients should assess their reaction before driving or operating machinery.
Lifestyle Advice
- Identify and avoid asthma triggers.
- Maintain a healthy lifestyle with regular exercise and a balanced diet.
- Discuss smoking cessation if applicable (for adult caregivers).
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.