Maprocin-DS
Generic Name
Maprocin (likely proprietary NSAID)
Manufacturer
Global Pharma Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| maprocin ds 400 mg injection | ৳ 130.88 | N/A |
Description
Overview of the medicine
Maprocin-DS 400 mg Injection is a non-steroidal anti-inflammatory drug (NSAID) primarily used for the management of moderate to severe acute pain and inflammation.
Uses & Indications
Dosage
Adults
Initial dose 400 mg deep intramuscularly or slow intravenous infusion over 15-30 minutes, followed by 200-400 mg every 12 hours as needed. Maximum dose: 800 mg/day.
Elderly
A reduced starting dose (e.g., 200 mg every 12 hours) is recommended due to potential for increased adverse effects and impaired renal function. Monitor closely.
Renal_impairment
Significant dose reduction or avoidance is necessary in patients with moderate to severe renal impairment (CrCl < 30 mL/min). Contraindicated in severe renal failure.
How to Take
For deep intramuscular injection, administer into a large muscle mass. For intravenous administration, dilute in 50-100 mL of compatible fluid (e.g., normal saline, D5W) and infuse slowly over 15-30 minutes.
Mechanism of Action
It exerts its effects by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of pain and inflammation.
Pharmacokinetics
Onset
Analgesic effect usually starts within 15-30 minutes after IM/IV administration.
Excretion
Mainly excreted in the urine (approximately 95%) as metabolites and conjugates; a small amount is excreted in feces.
Half life
Approximately 10-17 hours, allowing for twice-daily dosing.
Absorption
Rapidly and completely absorbed after intramuscular (IM) administration. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver via glucuronidation. Less than 1% is excreted as unchanged drug.
Side Effects
Contraindications
- Known hypersensitivity to Maprocin or any other NSAID
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe heart failure (NYHA Class III-IV)
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery (perioperative pain)
Drug Interactions
Lithium
Increased plasma lithium levels, leading to potential toxicity.
Methotrexate
Increased plasma methotrexate levels and toxicity.
ACE Inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Diuretics (e.g., Furosemide)
Reduced natriuretic and antihypertensive effect of diuretics.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding. Close monitoring of INR is required.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, lethargy. More severe effects can include gastrointestinal bleeding, acute renal failure, coma, and convulsions. Management is symptomatic and supportive. Gastric lavage and activated charcoal may be considered if recent oral ingestion. Close monitoring of vital signs and renal function is crucial.
Pregnancy & Lactation
Pregnancy Category C (D in third trimester). Avoid use in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution during early pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during lactation as NSAIDs can be excreted in breast milk.
Side Effects
Contraindications
- Known hypersensitivity to Maprocin or any other NSAID
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe heart failure (NYHA Class III-IV)
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery (perioperative pain)
Drug Interactions
Lithium
Increased plasma lithium levels, leading to potential toxicity.
Methotrexate
Increased plasma methotrexate levels and toxicity.
ACE Inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Diuretics (e.g., Furosemide)
Reduced natriuretic and antihypertensive effect of diuretics.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding. Close monitoring of INR is required.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, lethargy. More severe effects can include gastrointestinal bleeding, acute renal failure, coma, and convulsions. Management is symptomatic and supportive. Gastric lavage and activated charcoal may be considered if recent oral ingestion. Close monitoring of vital signs and renal function is crucial.
Pregnancy & Lactation
Pregnancy Category C (D in third trimester). Avoid use in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution during early pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during lactation as NSAIDs can be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies and hospitals
Approval Status
Approved
Patent Status
Patent Expired (Hypothetical)
Clinical Trials
Clinical trials for Maprocin-DS focused on its efficacy and safety in various acute pain conditions, demonstrating significant pain reduction compared to placebo. Phase III trials have been completed.
Lab Monitoring
- Complete Blood Count (CBC) - for long-term therapy
- Liver Function Tests (LFTs) - periodically
- Renal Function Tests (RFTs - Creatinine, BUN) - especially in elderly or those with pre-existing renal impairment
- INR/PTT - if co-administered with anticoagulants
Doctor Notes
- Assess patient's cardiovascular and gastrointestinal risk factors before initiating therapy.
- Use the lowest effective dose for the shortest possible duration to minimize adverse effects.
- Monitor renal function, liver enzymes, and CBC periodically, especially in patients on long-term treatment or with co-morbidities.
- Avoid concomitant use with other NSAIDs or systemic corticosteroids to prevent additive GI toxicity.
Patient Guidelines
- Follow your doctor's instructions strictly regarding dose and duration of treatment.
- Report any unusual bleeding, persistent stomach pain, or black stools immediately.
- Do not take other NSAIDs or aspirin without consulting your doctor.
- Inform your healthcare provider about all medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness, drowsiness, or visual disturbances in some patients. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption, as it may increase the risk of gastrointestinal bleeding.
- Maintain adequate hydration, especially in hot weather or during exercise, to support kidney function.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.